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Table 2 Sensitivity analysis of the effects of ramosetron vs placebo in irritable bowel syndrome with diarrhea

From: Ramosetron for the treatment of irritable bowel syndrome with diarrhea: a systematic review and meta-analysis of randomized controlled trials

  Study removed Ramosetron Placebo Pooled relative risks(RRs) with 95% confidence interval(CI)
Events Total Events Total
Relief of overall IBS symptoms None 372 803 216 801 1.70 [1.48, 1.95]
Matsueda K 2008a [25] 249 540 145 536 1.70 [1.40, 2.06]
Matsueda K 2008b [26] 329 702 188 697 1.73 [1.47, 2.03]
Fukudo S 2014 [22] 314 656 190 653 1.64 [1.42, 1.89]
Fukudo S 2015 [23] 224 511 125 517 1.80 [1.50, 2.15]
Relief of abdominal discomfort/pain None 368 803 259 801 1.41 [1.24, 1.59]
Matsueda K 2008a [25] 248 540 171 536 1.43 [1.22, 1.66]
Matsueda K 2008b [26] 330 702 232 697 1.40 [1.23, 1.60]
Fukudo S 2014 [22] 308 656 222 653 1.38 [1.20, 1.57]
Fukudo S 2015 [23] 218 511 152 517 1.44 [1.22, 1.71]
Improvement in abnormal bowel habits None 358 803 205 801 1.72 [1.50, 1.98]
Matsueda K 2008a [25] 243 540 142 536 1.69 [1.38, 2.06]
Matsueda K 2008b [26] 314 702 174 697 1.77 [1.52, 2.06]
Fukudo S 2014 [22] 306 656 182 653 1.66 [1.44, 1.93]
Fukudo S 2015 [23] 211 511 117 517 1.80 [1.46, 2.23]
Improvement in stool consistency None 184 439 106 432 1.71 [1.40, 2.08]
Fukudo S 2014 [22] 119 292 69 284 1.68 [1.31, 2.15]
Fukudo S 2015 [23] 65 147 37 148 1.77 [1.27, 2.47]