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Table 2 Phase-specific correlation of HBcrAg and HBsAg with various biomarkers

From: Distinct patterns of serum hepatitis B core-related antigen during the natural history of chronic hepatitis B

  Immune Tolerant
(n = 159)
Immune clearance
(n = 134)
Low Replicative
(n = 99)
HBeAg negativ hepatitis
(n = 54)
  r P r P r P r P
HBcrAg
 HBV DNA (log IU/ml) 0.683 <0.001 0.397 <0.001 0.023 0.822 0.583 <0.001
 HBeAg (log COI) 0.761 <0.001 0.652 <0.001 NA NA NA NA
 HBsAg (log IU/ml) 0.668 <0.001 0.521 <0.001 0.368 <0.001 0.296 0.03
 ALT IU/L −0.78 0.330 0.082 0.133 0.06 0.555 0.126 0.365
HBsAg
 HBV DNA (log IU/ml) 0.679 <0.001 0.608 <0.001 0.224 0.026 0.380 0.005
 HBeAg (log COI) 0.624 <0.001 0.456 <0.001 NA NA NA NA
 HBcrAg (log IU/ml) 0.668 <0.001 0.521 <0.001 0.368 <0.001 0.296 0.030
 ALT IU/L −0.08 0.271 0.104 0.231 0.015 0.879 −0.092 0.509
  1. The r and P values of the correlation analyses were in bold if statistical significance is prominent (p<0.001)