Distinct patterns of serum hepatitis B core-related antigen during the natural history of chronic hepatitis B

BMC Gastroenterology

Table 2 Phase-specific correlation of HBcrAg and HBsAg with various biomarkers

	Immune Tolerant (n = 159)		Immune clearance (n = 134)		Low Replicative (n = 99)		HBeAg negativ hepatitis (n = 54)
	r	P	r	P	r	P	r	P
HBcrAg
HBV DNA (log IU/ml)	0.683	<0.001	0.397	<0.001	0.023	0.822	0.583	<0.001
HBeAg (log COI)	0.761	<0.001	0.652	<0.001	NA	NA	NA	NA
HBsAg (log IU/ml)	0.668	<0.001	0.521	<0.001	0.368	<0.001	0.296	0.03
ALT IU/L	−0.78	0.330	0.082	0.133	0.06	0.555	0.126	0.365
HBsAg
HBV DNA (log IU/ml)	0.679	<0.001	0.608	<0.001	0.224	0.026	0.380	0.005
HBeAg (log COI)	0.624	<0.001	0.456	<0.001	NA	NA	NA	NA
HBcrAg (log IU/ml)	0.668	<0.001	0.521	<0.001	0.368	<0.001	0.296	0.030
ALT IU/L	−0.08	0.271	0.104	0.231	0.015	0.879	−0.092	0.509

The r and P values of the correlation analyses were in bold if statistical significance is prominent (p<0.001)

ISSN: 1471-230X