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Table 1 Baseline characteristics of enrolled patients

From: Distinct patterns of serum hepatitis B core-related antigen during the natural history of chronic hepatitis B

  Immune Tolerant
(n = 158)
Immune clearance
(n = 133)
Low Replicative
(n = 99)
HBeAg negativ hepatitis
(n = 54)
p value
Age 34 (28–42) 31 (26–39) 42 (32/49) 43 (37–52) <0.001a
Gender M/F 92/66 94/39 58/41 39/15 0.053b
ALT IU/L 40.5 (24–58.5) 175 (103–356) 22 (14–30) 160 (112–391) <0.001a
HBV DNA log IU/ml 7.65(6.45–7.70) 7.50 (6.65–7.69) <2.70 (<2.70–2.73) 5.81 (5.10–6.74) <0.001a
HBsAg log IU/ml 4.43 (3.54–4.76) 3.96 (3.55–4.52) 3.96 (3.56–4.51) 3.28 (2.78–3.69) <0.001a
HBeAg log COI 2.97 (1.93–3.13) 2.80 (2.12–3.08) Negative negative
Necro-inflammation
(G1:G2:G3)
109:23:26 36:50:47 82:10:7 18:17:19 <0.001a
Fibrosis:
(S1, S2, S3, S4)
84:38:16:20 33:48:20:32 65:13:10:11 13:15:12:14 <0.001a
Liver HBsAg
(0:1:2:3)
1:29:71:57 3:30:44:56 20:38:25:16 2:13:22:17 <0.001a
Liver HBcAg
(0:1:2)
78:50:30 85:38:10 96:2:1 49:5:0 <0.001a
  1. Data expressed as the median (interquartile range)
  2. aKruskall–Wallis analysis
  3. bchi square test