Table 1 Baseline characteristics of enrolled patients

Age

34 (28–42)

31 (26–39)

42 (32/49)

43 (37–52)

<0.001^a

Gender M/F

92/66

94/39

58/41

39/15

0.053^b

ALT IU/L

40.5 (24–58.5)

175 (103–356)

22 (14–30)

160 (112–391)

<0.001^a

HBV DNA log IU/ml

7.65(6.45–7.70)

7.50 (6.65–7.69)

<2.70 (<2.70–2.73)

5.81 (5.10–6.74)

<0.001^a

HBsAg log IU/ml

4.43 (3.54–4.76)

3.96 (3.55–4.52)

3.96 (3.56–4.51)

3.28 (2.78–3.69)

<0.001^a

HBeAg log COI

2.97 (1.93–3.13)

2.80 (2.12–3.08)

Negative

negative

–

Necro-inflammation

(G1:G2:G3)

109:23:26

36:50:47

82:10:7

18:17:19

<0.001^a

Fibrosis:

(S1, S2, S3, S4)

84:38:16:20

33:48:20:32

65:13:10:11

13:15:12:14

<0.001^a

Liver HBsAg

(0:1:2:3)

1:29:71:57

3:30:44:56

20:38:25:16

2:13:22:17

<0.001^a

Liver HBcAg

(0:1:2)

78:50:30

85:38:10

96:2:1

49:5:0

<0.001^a