Table 3 Multivariate Cox porportional hazard model for virological relapse with off-therapy HBsAg level as a time-varying variable
Variables | Adjusted HR | 95% CI | P |
|---|---|---|---|
Time-varying HBsAg level, log IU/mL | 2.10 | 1.45, 3.04 | <0.0001 |
Male sex | 1.33 | 0.58, 3.05 | 0.49 |
EOT age, year | 1.04 | 1.02, 1.06 | 0.0005 |
EOT ALT, U/L | 1.02 | 1.01, 1.02 | <0.0001 |
EOT AFP, ng/mL | 1.06 | 0.96, 1.16 | 0.24 |
EOT anti-HBe-seropositive | 0.46 | 0.16, 1.29 | 0.14 |
Pretreatment viral DNA, log IU/mL | 1.06 | 0.90, 1.25 | 0.52 |
Pretreatment HBeAg-positive | 2.58 | 0.53, 12.50 | 0.24 |
Pretreatment anti-HBe-positive | 4.02 | 0.88, 18.3 | 0.07 |