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Table 3 Multivariate Cox porportional hazard model for virological relapse with off-therapy HBsAg level as a time-varying variable

From: Time-varying serum gradient of hepatitis B surface antigen predicts risk of relapses after off-NA therapy

Variables Adjusted HR 95% CI P
Time-varying HBsAg level, log IU/mL 2.10 1.45, 3.04 <0.0001
Male sex 1.33 0.58, 3.05 0.49
EOT age, year 1.04 1.02, 1.06 0.0005
EOT ALT, U/L 1.02 1.01, 1.02 <0.0001
EOT AFP, ng/mL 1.06 0.96, 1.16 0.24
EOT anti-HBe-seropositive 0.46 0.16, 1.29 0.14
Pretreatment viral DNA, log IU/mL 1.06 0.90, 1.25 0.52
Pretreatment HBeAg-positive 2.58 0.53, 12.50 0.24
Pretreatment anti-HBe-positive 4.02 0.88, 18.3 0.07
  1. Notes. AFP alpha-fetoprotein, ALT Alanine transaminase, CI confidence interval, EOT end-of-therapy, HBeAg hepatitis B e antigen, HBsAg hepatitis B surface antigen, HR hazard ratio