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Table 3 Stratified analyses of unadjusted odds ratio of CCA by study characteristics

From: Non-alcoholic fatty liver disease as a risk factor for cholangiocarcinoma: a systematic review and meta-analysis

Groups # of studies Studies Number of patients Pooled OR (95% CI) Heterogeneity
Case Control P value I 2 (%)
Total With NAFLD Total With NAFLD
All CCAs 7 [9, 10, 16,17,18,19,20] 9102 426 129,111 1018 1.95 (1.36–2.79) <0.01 76
CCA subtype
 iCCA 6 [9, 10, 16, 17, 19, 20] 5067 264 120,233 816 2.22 (1.52–3.24) 0.01 67
 eCCA 4 [10, 16,17,18] 4035 162 116,429 736 1.55 (1.03–2.33) 0.02 69
Study region
 Asian 4 [9, 17, 18, 20] 5589 283 21,493 459 2.13 (1.47–3.10) 0.19 37
 Western 3 [10, 16, 19] 3513 143 107,618 559 1.83 (1.05–3.18) 0.06 65
Study quality
 Good 4 [16, 18,19,20] 2827 157 5632 242 1.33 (1.07–1.65) 0.39 0
 Fair 3 [9, 10, 17] 6275 269 123,479 776 2.48 (2.13–2.90) 0.79 0
  1. CCA Cholangiocarcinoma, eCCA Extrahepatic cholangiocarcinoma, iCCA Intrahepatic cholangiocarcinoma, OR Odds ratio