Non-alcoholic fatty liver disease as a risk factor for cholangiocarcinoma: a systematic review and meta-analysis

BMC Gastroenterology

Table 3 Stratified analyses of unadjusted odds ratio of CCA by study characteristics

Groups	# of studies	Studies	Number of patients				Pooled OR (95% CI)	Heterogeneity
			Case		Control			P value	I ² (%)
			Total	With NAFLD	Total	With NAFLD		P value	I ² (%)
All CCAs	7	[9, 10, 16,17,18,19,20]	9102	426	129,111	1018	1.95 (1.36–2.79)	<0.01	76
CCA subtype
iCCA	6	[9, 10, 16, 17, 19, 20]	5067	264	120,233	816	2.22 (1.52–3.24)	0.01	67
eCCA	4	[10, 16,17,18]	4035	162	116,429	736	1.55 (1.03–2.33)	0.02	69
Study region
Asian	4	[9, 17, 18, 20]	5589	283	21,493	459	2.13 (1.47–3.10)	0.19	37
Western	3	[10, 16, 19]	3513	143	107,618	559	1.83 (1.05–3.18)	0.06	65
Study quality
Good	4	[16, 18,19,20]	2827	157	5632	242	1.33 (1.07–1.65)	0.39	0
Fair	3	[9, 10, 17]	6275	269	123,479	776	2.48 (2.13–2.90)	0.79	0

CCA Cholangiocarcinoma, eCCA Extrahepatic cholangiocarcinoma, iCCA Intrahepatic cholangiocarcinoma, OR Odds ratio

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