Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice

Table 2 Histological analysis of H&E-stained liver sections of mice in each group

	NC-S	FF-S	NC-A	FF-A	p-Value
Steatosis (0–3)	0.0 ± 0	2.75 ± 0.10	0.0 ± 0	2.94 ± 0.18	0.181†
Lobular inflammation (0–3)	0.0 ± 0	1.58 ± 0.23	0.0 ± 0	1.67 ± 0.14	0.957†
Hepatocellular ballooning (0–2)	0.0 ± 0	0.17 ± 0.14	0.0 ± 0	0.88 ± 0.13	0.006†
NAS	0.0 ± 0	4.50 ± 0.22	0.0 ± 0	5.38 ± 0.32	0.034†
Centrizonal necrosis (0–3)	0.0 ± 0	0.0 ± 0	1.75 ± 0.30	0.0 ± 0	–

Results are presented as mean ± SEM
The degree of necrosis was expressed as the mean of 10 different fields and has been classified as 0, normal; 1, mild; 2, moderate; 3, severe. †Student’s t-test to determine differences between mice in the FF-S and FF-A groups
FF-A mice fed the fast food diet and injected with APAP (n = 8), NAS non-alcoholic fatty liver disease activity score, NC-A mice fed the normal chow diet and injected with acetaminophen (n = 8)

ISSN: 1471-230X