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Table 2 Histological analysis of H&E-stained liver sections of mice in each group

From: Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice

  NC-S FF-S NC-A FF-A p-Value
Steatosis (0–3) 0.0 ± 0 2.75 ± 0.10 0.0 ± 0 2.94 ± 0.18 0.181†
Lobular inflammation (0–3) 0.0 ± 0 1.58 ± 0.23 0.0 ± 0 1.67 ± 0.14 0.957†
Hepatocellular ballooning (0–2) 0.0 ± 0 0.17 ± 0.14 0.0 ± 0 0.88 ± 0.13 0.006†
NAS 0.0 ± 0 4.50 ± 0.22 0.0 ± 0 5.38 ± 0.32 0.034†
Centrizonal necrosis (0–3) 0.0 ± 0 0.0 ± 0 1.75 ± 0.30 0.0 ± 0
  1. Results are presented as mean ± SEM
  2. The degree of necrosis was expressed as the mean of 10 different fields and has been classified as 0, normal; 1, mild; 2, moderate; 3, severe. †Student’s t-test to determine differences between mice in the FF-S and FF-A groups
  3. FF-A mice fed the fast food diet and injected with APAP (n = 8), NAS non-alcoholic fatty liver disease activity score, NC-A mice fed the normal chow diet and injected with acetaminophen (n = 8)