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Table 1 Gene Ontology enrichment analysis of genes in the ten network modules

From: miR-363-5p as potential prognostic marker for hepatocellular carcinoma indicated by weighted co-expression network analysis of miRNAs and mRNA

Module Gene number Functional Ontology (top) p value Discription
Plum 52 keratinization 1.50E-25 Protein involved in keratinization, the process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.
Antique white 122 erythrocyte 1.20E-09 Protein involved in the maturation of erythrocytes, the predominant type of cells present in vertebrate blood and which contain the gas-transporting protein, hemoglobin.
Coral 1488 oxidoreductase 4.20E-49 Enzyme that catalyzes the oxidation of one compound with the reduction of another.
Ivory 124 Secreted 6.20E-11 Protein secreted into the cell surroundings.
Light cyan 3299 acetylation 4.90E-92 Protein which is posttranslationally modified by the attachment of at least one acetyl group; generally at the N-terminus.
Medium purple 35 cell membrane 6.20E-03 Protein found in or associated with the cytoplasmic membrane, a selectively permeable membrane which separates the cytoplasm from its surroundings. Known as the cell inner membrane in prokaryotes with 2 membranes.
Brown 99 glycoprotein 3.90E-04 Protein containing one or more covalently linked carbohydrates of various types, i.e. from monosaccharides to branched polysaccharides, including glycosylphosphatidylinositol (GPI), glycosaminoglycans (GAG).
Dark magenta 8695 alternative splicing 3.20E-39 Protein for which at least two isoforms exist due to distinct pre-mRNA splicing events.
Pale violetred 46 chromosomal protein 1.00E-08 Protein which is associated with chromosomal DNA, including histones, protamines and high mobility group proteins.
Grey 6199 sensory transduction 3.40E-13 Protein involved in sensory transduction, the process by which a cell converts an extracellular signal, such as light, taste, sound, touch or smell, into electric signals.