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Table 2 Histopathological alterations in constipated SD rats after Urd treatment

From: Uridine stimulate laxative effect in the loperamide-induced constipation of SD rats through regulation of the mAChRs signaling pathway and mucin secretion

Contents

No

Urd

Lop

Vehicle

Urd

Mucosa layer thickness (μm)

394 ± 35.2

415 ± 21.3

105 ± 12.5*

402 ± 23.5#

Muscle thickness (μm)

89.3 ± 6.5

92.3 ± 7.6

28.3 ± 4.3*

90.2 ± 6.6#

Flat luminal surface thickness (μm)

16.1 ± 3.2

15.4 ± 2.3

10.6 ± 1.1*

14.8 ± 2.0#

Number of goblet cells (ea)

85.6 ± 8.5

88.4 ± 6.7

51.2 ± 5.5*

72.6 ± 9.8#

Number of crypt of lieberkuhn (ea)

12.5 ± 2.6

14.2 ± 1.5

5.8 ± 1.1*

11.2 ± 2.1#

Number of enterocytes (ea)

125.2 ± 8.6

117.8 ± 7.7

82.3 ± 9.2*

102.4 ± 7.8#

  1. *p < 0.05 compared with the non-constipation group. # p < 0.05 compared with the Lop + Vehicle treated constipation group. Urd; uridine, Lop; loperamide