Table 3 Relationships between gene expression and clinical characteristics (Continued Table 2)
Clinical features | TUBB3 | STMN1 | TOP2A | ||||||
|---|---|---|---|---|---|---|---|---|---|
Low | Middle | High | Low | Middle | High | Low | Middle | High | |
Gender | |||||||||
 Male | 22 (28.9) | 41 (53.9) | 13 (17.1) | 27 (35.5) | 36 (47.4) | 13 (17.1) | 9 (11.8) | 45 (59.2) | 22 (28.9) |
 Female | 13 (59.1) | 8 (36.4) | 1 (4.5) | 7 (31.8) | 12 (54.5) | 3 (13.6) | 5 (22.7) | 11 (80.0) | 6 (27.3) |
χ 2, P | 7.280, 0.026 | 0.373, 0.830 | 1.685, 0.431 | ||||||
Age | |||||||||
  < 57 years | 21 (51.2) | 16 (39.0) | 4 (9.8) | 19 (46.3) | 19 (46.3) | 3 (7.3) | 8 (19.5) | 24 (58.5) | 9 (22.0) |
  > 57 years | 14 (24.6) | 33 (57.9) | 10 (17.5) | 15 (26.3) | 29 (50.9) | 13 (22.8) | 6 (10.5) | 32 (56.1) | 19 (33.3) |
χ 2, P | 7.464, 0.024 | 6.361, 0.042 | 2.453, 0.293 | ||||||
Family history | |||||||||
 Yes | 4 (80.0) | 0 (0.0) | 1 (20.0) | 2 (40.0) | 3 (60.0) | 0 (0.0) | 2 (40.0) | 2 (40.0) | 1 (20.0) |
 No | 31 (33.3) | 49 (52.7) | 13 (14.0) | 32 (34.4) | 45 (48.4) | 16 (17.2) | 12 (12.9) | 54 (58.1) | 27 (29.0) |
χ 2, P | 7.414, 0.025 | 1.839, 0.399 | 2.128, 0.345 | ||||||
Alcohol history | |||||||||
 Yes | 10 (31.3) | 17 (53.1) | 5 (15.6) | 12 (37.5) | 13 (40.6) | 7 (21.9) | 3 (9.4) | 18 (56.3) | 11 (34.4) |
 No | 25 (37.9) | 32 (48.5) | 9 (13.6) | 22 (33.3) | 35 (53.0) | 9 (13.6) | 11 (16.7) | 38 (57.6) | 17 (25.8) |
| Â | 0.418, 0.812 | 1.681, 0.432 | 1.369, 0.504 | ||||||
Histological type | |||||||||
 Tubular adenocarcinoma | 29 (38.7) | 34 (45.3) | 12 (16.0) | 23 (30.7) | 38 (50.7) | 14 (18.7) | 10 (13.3) | 40 (53.3) | 25 (33.3) |
 Non-tubular adenocarcinoma | 6 (26.1) | 15 (65.2) | 2 (8.7) | 11 (47.8) | 10 (43.5) | 2 (8.7) | 4 (17.4) | 16 (69.6) | 3 (13.0) |
χ 2, P | 2.829, 0.243 | 0.751, 0.253 | 3.551, 0.169 | ||||||
Differentiation | |||||||||
 Undifferentiated | 5 (33.3) | 10 (66.7) | 0 (0.0) | 8 (53.3) | 6 (40.0) | 1 (6.7) | 3 (20.0) | 9 (60.0) | 3 (20.0) |
 Poor | 20 (33.3) | 29 (48.3) | 11 (18.3) | 19 (31.7) | 32 (53.3) | 9 (15.0) | 7 (11.7) | 34 (56.7) | 19 (31.7) |
 Moderate | 9 (40.9) | 10 (45.5) | 3 (13.6) | 7 (31.8) | 10 (45.5) | 5 (22.7) | 4 (18.2) | 13 (59.1) | 5 (22.7) |
 Well | 1 (100.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (100.0) | 0 (0.0) | 0 (0.0) | 1 (100.0) |
χ 2, P | 8.144, 0.228 | 7.341, 0.290 | 4.279, 0.639 | ||||||
Growth patterns | |||||||||
 Expansive | 1 (50.0) | 1 (50.0) | 0 (0.0) | 2 (100.0) | 0 (0.0) | 0 (0.0) | 1 (50.0) | 1 (50.0) | 0 (0.0) |
 Invasive | 24 (33.8) | 34 (47.9) | 13 (18.3) | 21 (29.6) | 36 (50.7) | 14 (19.7) | 9 (12.7) | 42 (59.2) | 20 (28.2) |
 Expansive + invasive | 10 (40.0) | 14 (56.0) | 1 (4.0) | 10 (40.0) | 11 (44.0) | 12 (48.0) | 4 (16.0) | 13 (52.0) | 8 (32.0) |
χ 2, P | 4.443, 0.349 | 7.200, 0.126 | 2.694, 0.610 | ||||||
Metastasis | |||||||||
 Yes | 14 (26.9) | 29 (55.8) | 9 (17.3) | 16 (30.8) | 26 (50.0) | 10 (19.2) | 5 (9.6) | 30 (57.7) | 17 (32.7) |
 No | 21 (45.7) | 20 (43.5) | 5 (10.9) | 18 (39.1) | 22 (47.8) | 6 (13.0) | 9 (19.6) | 26 (56.5) | 11 (23.9) |
χ 2, P | 3.843, 0.146 | 1.088, 0.581 | 2.356, 0.308 | ||||||
Depth of invasion | |||||||||
 T1 | 6 (42.9) | 8 (57.1) | 0 (0.0) | 5 (35.7) | 8 (57.1) | 1 (7.1) | 5 (35.7) | 5 (35.7) | 4 (28.6) |
 T2 | 2 (40.0) | 2 (40.0) | 1 (20.0) | 1 (20.0) | 2 (40.0) | 2 (40.0) | 0 (0.0) | 4 (80.0) | 1 (20.0) |
 T3 | 1 (33.3) | 1 (33.3) | 1 (33.3) | 0 (0.0) | 1 (33.3) | 2 (66.6) | 0 (0.0) | 1 (33.3) | 2 (66.6) |
 T4 | 26 (34.2) | 38 (50.0) | 12 (15.8) | 28 (36.8) | 37 (48.7) | 11 (14.5) | 9 (11.8) | 46 (60.5) | 21 (27.6) |
χ 2, P | 5.469, 0.485 | 7.900, 0.246 | 9.263, 0.159 | ||||||
Lymph node metastasis | |||||||||
 N0 | 22 (42.3) | 25 (48.1) | 5 (9.6) | 20 (38.5) | 26 (50.0) | 6 (11.5) | 9 (17.3) | 31 (59.6) | 12 (23.1) |
 N1 | 6 (18.8) | 19 (59.4) | 7 (21.9) | 10 (31.3) | 14 (43.8) | 8 (25.0) | 4 (12.8) | 17 (53.1) | 11 (34.4) |
 N2 | 5 (45.5) | 4 (36.4) | 2 (18.2) | 4 (36.4) | 5 (45.5) | 2 (18.2) | 0 (0.0) | 8 (72.7) | 3 (27.3) |
Undetermined | 2 (66.7) | 1 (33.3) | 0 (0.0) | 0 (0.0) | 3 (100.0) | 0 (0.0) | 1 (33.3) | 0 (0.0) | 2 (66.7) |
χ 2, P | 8.812, 0.184 | 6.938, 0.327 | 10.139, 0.119 | ||||||
Distant metastasis | |||||||||
 M0 | 31 (36.0) | 41 (51.2) | 11 (12.8) | 33 (38.4) | 39 (45.3) | 14 (16.3) | 12 (14.0) | 51 (59.3) | 23 (26.7) |
 M1 | 4 (33.3) | 5 (41.7) | 3 (25.0) | 1 (8.3 | 9 (75.0) | 2 (16.7) | 2 (16.7) | 5 (41.7) | 5 (41.7) |
χ 2, P | 1.148, 0.563 | 5.461, 0.065 | 1.410, 0.494 | ||||||
TNM staging | |||||||||
 I | 8 (44.4) | 9 (50.0) | 1 (5.6) | 6 (33.3) | 9 (50.0) | 3 (16.7) | 5 (27.8) | 8 (44.4) | 5 (27.8) |
 IIA-IIC | 11 (37.9) | 15 (51.7) | 3 (10.3) | 11 (37.9) | 15 (51.7) | 3 (10.3) | 3 (10.3) | 20 (69.0) | 6 (20.7) |
 IIIA-IIIC | 12 (30.8) | 20 (51.3) | 7 (17.9) | 16 (41.0) | 15 (38.5) | 8 (20.5) | 4 (10.3) | 23 (59.0) | 12 (30.8) |
 IVA-IVB | 4 (33.3) | 5 (41.7) | 3 (25.0) | 1 (8.3) | 9 (75.0) | 2 (16.7) | 2 (16.7) | 5 (41.7) | 5 (41.7) |
χ 2, P | 3.629, 0.727 | 7.539, 0.274 | 5.869, 0.438 | ||||||