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Table 4 Joint effects of smoking, drinking and MTHFR C677T on pancreatic cancer risk

From: Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects

C677T Genotype Smoking Case patients Control subjects OR (95 % CI)
CC + CT Never 109 152 1.00
TT Never 36 50 1.04 (0.62-1.73)
CC + CT Ever 179 166 1.69 (1.13-2.54)
TT Ever 36 32 1.94 (1.05-3.57)
     P for interaction = 0.79
  Drinking Case patients Control subjects OR* (95 % CI)
CC + CT Never 105 120 1.00
TT Never 29 27 1.33 (0.72-2.45)
CC + CT Ever 183 198 1.10 (0.75-1.61)
TT Ever 43 55 1.05 (0.62-1.78)
     P for interaction = 0.38
  1. OR odds ratio, CI confidence interval
  2. *OR was adjusted for age, sex, body mass index, cigarette smoking and history of diabetes