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Table 2 Comparisons of baseline features of patients with sustained virological response (SVR) and those with non-SVR

From: Peripheral blood toll-like receptor 4 correlates with rapid virological response to pegylated-interferon and ribavirin therapy in hepatitis C genotype 1 patients

Variables SVR (N = 45) Non-SVR (N = 30) P value
Sex (M:F) 19:26 20:10 0.038
Age (median,IQR) 59.7 (51.1 ~ 67.4) 56.6 (45.9 ~ 64.7) 0.176
BMI, Kg/m2 (median,IQR) 23.9 (22.4 ~ 27.1) 23.7 (21.4 ~ 27.8) 0.787
ALT, IU/L(median,IQR) 84.0 (52.0 ~ 134.5) 77.0 (44.8 ~ 14.8) 0.423
Viral load (≥ vs < 4 × 105 IU/ml) 25:20 19:11 0.503
RVR (yes vs. no) 31:14 10:20 0.002
Liver cirrhosis (yes vs. no) 2:43 8:22 0.012
> 80 % adherence (yes vs. no) 32:13 21:9 0.918
rs12979860 (CC vs CT + TT) 43:2 20:10 0.002
rs 8099917 (TT vs GG + GT) 45:0 20:10 < 0.001
TLR2 mRNA (median,IQR) −1.07 (−4.05 ~ −0.74) −0.96 (−3.39 ~ −0.67) 0.304
TLR3 mRNA (median,IQR) −3.39 (−4.53 ~ −2.86) −3.28 (−4.10 ~ −2.90) 0.607
TLR4 mRNA (median,IQR) −1.24 (−4.05 ~ −0.96) −1.02 (−3.54 ~ −0.78) 0.067
TLR7 mRNA (median,IQR) −2.76 (−4.53 ~ −2.19) −2.42 (−4.18 ~ −2.20) 0.545
TLR9 mRNA (median,IQR) −2.85 (−4.57 ~ −2.59) −2.62 (−4.12 ~ −2.47) 0.124
  1. RVR rapid virological response, BMI body mass index, ALT alanine aminotransferase, TLR toll like receptor. TLR mRNA expression levels were shown as log ratios relative to GAPDH mRNA (log 2 -(∆Ct))
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