|
Variables
|
SVR (N = 45)
|
Non-SVR (N = 30)
|
P value
|
|---|
|
Sex (M:F)
|
19:26
|
20:10
|
0.038
|
|
Age (median,IQR)
|
59.7 (51.1 ~ 67.4)
|
56.6 (45.9 ~ 64.7)
|
0.176
|
|
BMI, Kg/m2 (median,IQR)
|
23.9 (22.4 ~ 27.1)
|
23.7 (21.4 ~ 27.8)
|
0.787
|
|
ALT, IU/L(median,IQR)
|
84.0 (52.0 ~ 134.5)
|
77.0 (44.8 ~ 14.8)
|
0.423
|
|
Viral load (≥ vs < 4 × 105 IU/ml)
|
25:20
|
19:11
|
0.503
|
|
RVR (yes vs. no)
|
31:14
|
10:20
|
0.002
|
|
Liver cirrhosis (yes vs. no)
|
2:43
|
8:22
|
0.012
|
|
> 80 % adherence (yes vs. no)
|
32:13
|
21:9
|
0.918
|
|
rs12979860 (CC vs CT + TT)
|
43:2
|
20:10
|
0.002
|
|
rs 8099917 (TT vs GG + GT)
|
45:0
|
20:10
|
< 0.001
|
|
TLR2 mRNA (median,IQR)
|
−1.07 (−4.05 ~ −0.74)
|
−0.96 (−3.39 ~ −0.67)
|
0.304
|
|
TLR3 mRNA (median,IQR)
|
−3.39 (−4.53 ~ −2.86)
|
−3.28 (−4.10 ~ −2.90)
|
0.607
|
|
TLR4 mRNA (median,IQR)
|
−1.24 (−4.05 ~ −0.96)
|
−1.02 (−3.54 ~ −0.78)
|
0.067
|
|
TLR7 mRNA (median,IQR)
|
−2.76 (−4.53 ~ −2.19)
|
−2.42 (−4.18 ~ −2.20)
|
0.545
|
|
TLR9 mRNA (median,IQR)
|
−2.85 (−4.57 ~ −2.59)
|
−2.62 (−4.12 ~ −2.47)
|
0.124
|
-
RVR rapid virological response, BMI body mass index, ALT alanine aminotransferase, TLR toll like receptor. TLR mRNA expression levels were shown as log ratios relative to GAPDH mRNA (log 2 -(∆Ct))
