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Table 1 Comparisons of baseline features of patients with rapid virological response (RVR) and those with non-RVR

From: Peripheral blood toll-like receptor 4 correlates with rapid virological response to pegylated-interferon and ribavirin therapy in hepatitis C genotype 1 patients

Variables RVR (N = 45) Non-RVR (N = 34) P value
Sex (M:F) 23:22 19:15 0.674
Age (median,IQR) 60.5 (52.9 ~ 67.8) 53.4 (43.9 ~ 63.0) 0.003
BMI, Kg/m2 (median,IQR) 23.5 (21.8 ~ 24.7) 26.4 (23.0 ~ 29.4) 0.001
ALT, IU/L(median,IQR) 71.0 (48.0 ~ 138.5) 84.5 (56.3 ~ 115.5) 0.801
HCV viral load (≥ vs < 4x105 IU/ml) 17:28 28:6 < 0.001
Liver cirrhosis (yes vs. no) 4:41 6:28 0.313
> 80 % adherence (yes vs. no) 32:13 24:10 0.960
rs12979860 (CC vs. CT + TT) 43:2 24:10 0.002
rs 8099917 (TT vs. GG + GT) 44:1 25:9 0.002
TLR2 mRNA (median,IQR) −1.36 (−2.52 ~ 0.76) 0.82 (0.55 ~ 0.96) 0.001
TLR3 mRNA (median,IQR) −2.66 (−3.13 ~ −1.28) −1.47 (−1.90 ~ −1.27) 0.014
TLR4 mRNA (median,IQR) −1.85 (−2.53 ~ 0.57) 0.66 (0.31 ~ 0.86) < 0.001
TLR7 mRNA (median,IQR) −2.41 (−3.19 ~ −0.07) −0.77 (−1.18 ~ −0.57) 0.008
TLR9 mRNA (median,IQR) −2.44 (−3.17 ~ −1.01) −0.98 (−1.26 ~ −0.84) 0.001
  1. BMI body mass index, ALT alanine aminotransferase, TLR toll like receptor, TLR mRNA expressions were shown as log ratios relative to GAPDH mRNA (log 2 -(∆Ct)). > 80 % adherence: patients who received more than 80 % of standard dose and duration
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