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Table 2 Clinical, serological and histological characteristics of celiac disease in 1358 patientsa

From: Type 1 and type 2 diabetes in celiac disease: prevalence and effect on clinical and histological presentation

  DM1 DM2 No diabetes  
n = 51 n = 38 n = 1269 P value
Females, % 39 61 74 <0.001
Current age, median (range), yr 45 (18–71) 65 (45–83) 52 (20–92) <0.001
Age at dg of CD, median (range), yr 38 (2–70) 53 (26–76) 42 (2–89) <0.001
Mode of presentation at dg, %     <0.001
Gastrointestinal symptoms 35 50 54  
Malabsorption 8 24 17  
Extra-intestinal symptomsb 14 13 16  
Risk-group screeningc 43 13 14  
Hb at dg, median (range), g/l 131 (114–152) 134 (112–165) 128 (39–174) 0.272
Anemia at dg, % 20 26 27 0.515
CD in relatives, % 58 61 60 0.964
Positive EmA at dg, % 100 91 88 0.431
Degree of villous atrophy, %     0.433
Total 42 36 31  
Subtotal 29 50 38  
Partial 29 14 31  
  1. DM1, type 1 diabetes; DM2, type 2 diabetes
  2. Hb hemoglobin, EmA endomysial antibodies
  3. aCeliac disease patients with or without concomitant DM1 or DM2
  4. bDermatitis herpetiformis, infertility, arthralgia or arthritis, osteoporosis, dental enamel defects, polyneuropathy, hypertransaminasemia, aphtous stomatitis
  5. cDM1, family history for celiac disease, autoimmune thyroid disease, Sjögren’s syndrome