Fig. 4
From: Deficiency of eNOS exacerbates early-stage NAFLD pathogenesis by changing the fat distribution
Analysis of the mechanism associated with the pathogenesis of NAFLD. a ITT results at 12 weeks showed no significant difference in the systemic response to insulin injection between the eNOS+/+/HFD mice and the eNOS-/-/HFD mice, while it was significantly lower in the eNOS+/+/HFD mice than in the eNOS+/+/BD mice, which were regarded as the control group. b The liver SREBP-1c and PPAR-α1 mRNA expression levels were comparable between the eNOS-/-/HFD mice and the eNOS-/-/HFD mice. The liver MTP activity level was significantly lower in the eNOS-/-/HFD mice than in the eNOS+/+/HFD mice at 12 weeks. The liver SREBP-1c mRNA expression level and the liver MTP activity level were significantly higher in the eNOS+/+/HFD mice than in the eNOS+/+/BD mice, which were regarded as the control group. (Data were expressed as the mean ± SEM. *P < 0.05, represents a significant difference; n.s. represents no significant difference.)