Table 2 Pre-transplant clinical history and transplantation of liver transplant recipients with NASH without pre-transplant DM
NASH w/o DM | Controls w/o DM | p | |
|---|---|---|---|
BMI | 30.1 ± 6.3 | 26.7 ± 5.6 | <0.0001 |
Overweight (BMI 25–30) | 871 (30.6 %) | 4,608 (33.0 %) | 0.0128 |
Obese (BMI > =30) | 1,333 (46.9 %) | 3,427 (24.6 %) | <0.0001 |
Chronic obstructive pulmonary disease | 29 (1.2 %) | 164 (1.4 %) | 0.47 |
Medically-treated hypertension | 574 (23.4 %) | 2,062 (17.2 %) | <0.0001 |
Coronary artery disease | 76 (3.1 %) | 184 (1.5 %) | <0.0001 |
Stroke | 21 (0.8 %) | 77 (0.6 %) | 0.24 |
Peripheral vascular disease | 24 (1.0 %) | 108 (0.9 %) | 0.73 |
Pulmonary embolism | 8 (0.3 %) | 45 (0.4 %) | 0.72 |
Malignancy (solid organ or lymphoproliferative) | 210 (7.2 %) | 1,544 (10.9 %) | <0.0001 |
Other solid organ transplants | 7 (0.2 %) | 106 (0.7 %) | 0.0022 |
Primary liver malignancy | 130 (4.5 %) | 2,202 (15.4 %) | <0.0001 |
TIPSS | 300 (10.4 %) | 1,073 (7.6 %) | <0.0001 |
Transplantation | |||
Last MELD score | 22.8 ± 8.5 | 22.2 ± 9.9 | <0.0001 |
Heterotopic transplant | 3 (0.1 %) | 15 (0.1 %) | 0.97 |
Transplant from a living donor | 97 (3.3 %) | 729 (5.1 %) | <0.0001 |
Donor’s age | 43.2 ± 17.4 | 41.4 ± 17.6 | <0.0001 |
Donor’s history of DM | 315 (11.2 %) | 1,357 (10.1 %) | 0.06 |
Procurement from a non-heart beating donor | 137 (4.9 %) | 572 (4.2 %) | 0.13 |
Number of HLA mismatches with a donor | 4.52 ± 1.15 | 4.55 ± 1.14 | 0.39 |
Immunosuppressants used at transplant: | |||
Mycophenolates | 2,275 (78.2 %) | 10,943 (76.9 %) | 0.14 |
Tacrolimus | 2,695 (92.6 %) | 13,235 (93.0 %) | 0.43 |
Steroids | 2,763 (94.9 %) | 13,519 (95.0 %) | 0.88 |
Rejection episode before discharge | 166 (6.2 %) | 999 (7.8 %) | 0.0031 |
Post-transplant inpatient stay, days | 16.0 ± 18.7 | 15.6 ± 19.9 | 0.0498 |
Total inpatient stay, days | 20.7 ± 36.2 | 20.1 ± 29.2 | 0.16 |
Non-compliant in follow-up (ever) | 104 (4.0 %) | 764 (6.0 %) | 0.0001 |