Comparison of 10-day sequential therapy with 7-day standard triple therapy for Helicobacter pylori eradication in inactive peptic ulcer disease and the efficiency of sequential therapy in inactive peptic ulcer disease and non-ulcer dyspepsia

Table 5 Multivariate analysis to investigate the independent factors

	Total (N = 408)	Eradication failure (N = 70)	Eradication success (N = 338)	p-value
Age (Mean ± SD)	51.2 ± 11.1	50.7 ± 10.5	51.3 ± 11.1	0.67
Gender (%)
Male	144	22 (31.4 %)	122 (36.1 %)	0.46
Female	264	48 (68.6 %)	216 (63.9 %)
Adverse event (%)
Yes	140	16 (22.9 %)	124 (36.7 %)	0.03
No	268	54 (77.1 %)	214 (63.3 %)
There is no statistically difference between eradication rate, gender, and age. The success group have more adverse event.
iDU	Total failure in iDU (N = 26)	Failure in Triple (N = 10)	Failure in Sequential (N = 16)	p-value
Age (Mean ± SD)	51.7 ± 9.7	48.5 ± 7.9	53.7 ± 10.4	0.19
Gender (%)
Male	9	3 (30.0 %)	6 (37.5 %)	0.7
Female	17	7 (70.0 %)	10 (62.5 %)
Adverse event (%)
Yes	10	2 (20.0 %)	8 (50.0 %)	0.13
No	16	8 (80.0 %)	8 (50.0 %)
In iDU group, there is no statistically difference between failure rate, age, gender, and adverse, event.
Sequential	Total failure in Sequential (N = 60)	Failure in iDU (N = 16)	Failure in NUD (N = 44)	p-value
Age (Mean ± SD)	51.0 ± 10.9	53.7 ± 10.4	50.0 ± 11.0	0.26
Gender (%)
Male	19	6 (37.5 %)	13 (29.5 %)	0.56
Female	41	10 (62.5 %)	31 (70.5 %)
Adverse event (%)
Yes	14	8 (50.0 %)	6 (13.6 %)	0.003
No	46	8 (50.0 %)	38 (86.4 %)
In sequential group, there is no statistically difference between failure rate, age, and gender. However, the adverse rate is statistically higher in iDU group.

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