An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohn’s disease

Table 2 Changes in leucocyte count, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) following intensive and weekly GMA in Crohn’s disease patients

Measurement	Time point	Intensive GMA	Weekly GMA	P value*, intensive vs weekly
Leucocyte (/μL)	Baseline	8005 [6290–9378]	7100 [5340–7915]	0.0273
	Post GMA	6950 [5400–8775]	7160 [5338–8465]	0.8601
P value**
Baseline vs Post GMA		0.0461	0.6260
ESR (mm/hr)	Baseline	54.5 [37.0–68.0]	24.5 [9.7–52.5]	0.014
	Post GMA	30.0 [10.5–51.5]	26.0 [7.0–47.0]	0.5480
P value**
Baseline vs Post GMA		0.0059	0.6553
CRP (mg/dL)	Baseline	1.90 [0.60–4.05]	0.90 [0.40–2.62]	0.0478
	Post GMA	0.80 [0.12–2.30]	0.35 [0.195–1.27]	0.4464
P value**
Baseline vs Post GMA		0.0941	0.0277

Data are represented as the median [interquartile range]
*Compared by Wilcoxon-Mann–Whitney test
**Compared by Wilcoxon-Signed-Rank test. GMA, granulocyte and monocyte adsorptive apheresis. For ESR, the number of patients at baseline in the intensive and the weekly GMA arms were 22 and 24, respectively. Normal range: leucocyte 4000–9000/μL, CRP < 0.3 mg/dL, ESR < 10 mm/hr (male); < 15 mm/hr (female)

ISSN: 1471-230X