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Table 2 Characteristic of selected studies in the meta-analysis

From: Prognostic and clinical significance of syndecan-1 in colorectal cancer: a meta-analysis

Author Clinical parameters assessment (number) Scoring system (Positivity cells) Number of patients Epitope retrieval method
Wang et al T, L, H, D, F. (52) histoscore = area × intensitya High level (26), Low level (26) NA
Yang et al F. (58) histoscore = area × intensitya Positive (19), Negative (39) HIER
Pap et al T, L, H, D. (117) Frequency of cells + intensityb G0 (2), G1-3 (115) pressurized steam cooking
Hashimoto et al T, L, H, D, F. (131) 0 (< 5 %); 1+ (5 % – 25 %); 2+ (25 % – 75 %), 3+ (> 75 %) 0 (38), 1+(27), 2+(49), 3+(17) antigen retrieval solution
Qi et al T, L, H, D, E. (52) 0 (< 5 %); 1+ (5 % – 25 %); 2+ (25 % – 75 %), 3+ (> 75 %) Positive (34), Negative (18) HIER
Feng et al T, L, H, D, E. (31) 0 (< 5 %); 1+ (5 % – 25 %); 2+ (25 % – 75 %), 3+ (> 75 %) Positive (25), Negative (6) HIER
Lundin et al T, H, F. (237) Weak: < 30 %, Strong: > 30 % Weak (86), Strong (151) NA
Zhou et al T, L, H. (52) 0 (< 5 %); 1+ (5 % – 25 %); 2+ (25 % – 75 %), 3+ (> 75 %) 0 (18), 1+(13), 2+(14), 3+(7) HIER
Zuo et al T, L, H, D, E. (51) 0 (< 5 %); 1+ (5 % – 50 %); 2+ (> 50 %) 0 (31), 1+(17), 2+ (3) HIER
Fujiya et al T, L, F. (105) – (< 5 %); + (5 % – 25 %); ++ (25 % – 75 %), +++ (> 75 %) – & ± (36), + & ++ (69) HIER
  1. NA not available, T depth of infiltration, L lymph node metastasis, D distant metastasis, H Histological grade, F follow-up, E expression of tumor, HIER heat induced epitope retrieval
  2. aThe intensity of membranous staining was graded as negative (-), weak (+), moderate (++) and intense (+++). The percentage of cells was graded as follows: 0 (<5 %), 1 (5–25 %), 2 (26–50 %), 3 (51–75 %) and 4 (> 75 %). Imunohistochemical score (histoscore) = values of the intensity × the percentage of cells (area).bFrequency (F) of immunopositive tumor cells: F0: 0–5 %, F1: 6–30 %, F2: 31–75 %, F3: 76– 100 %; and the signal intensity (I): absent (0), weak (1), moderate (2), strong (3). Immunohistochemical grading (IG) system: IG0 (absent): F+I= 0–1; IG1 (weak): F+I=2–3; IG2 (moderate): F+I= 4; IG3 (strong): F+I= 5–6