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Fig. 3 | BMC Gastroenterology

Fig. 3

From: Combination of sorafenib and gadolinium chloride (GdCl3) attenuates dimethylnitrosamine(DMN)-induced liver fibrosis in rats

Fig. 3

Effects of sorafenib and/or GdCl3 blockage on in vivo expression of proinflammatory cytokines in liver fibrosis. a CD68 immunohistochemistry (magnification X 400, n = 4). b Levels of mRNA encoded by genes encoding proinflammatory cytokines in rats with DMN-induced fibrosis (n = 6). c The Expression of CD68, TNF-α, IL1β, CCL2 was analyzed using western blot (n = 6). Control, vehicle alone; 4 W, DMN for 4 weeks; S, DMN for 4 weeks plus sorafenib for 2 weeks; G, DMN for 4 weeks plus GdCl3 for 2 weeks; S + G, DMN for 4 weeks plus sorafenib and GdCl3 for 2 weeks. Results reported as mean ± S.D. *p < 0.05; **p < 0.01 vs 4 W

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