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Table 5 Clinical features of refractory and non-refractory groups

From: Evaluation of the role of HLA-DR antigens in Japanese type 1 autoimmune hepatitis

  Non-refractory group (n = 106) Refractory group (n = 15) P-value
Discrete traits N (%) N (%)  
 Sex    0.356
  Male 11 (10.4) 0 (0)  
  Female 95 (89.6) 15 (100)  
Pattern of disease onset 45 (42.5) 2 (13.3) 0.045
 Acute onset
 Other autoimmune diseases 19 (17.9) 3 (20.0) 0.735
Death from liver disease-related causes 0 (0) 8 (53.3) <0.001
 ANA positivity 92 (86.8) 13 (86.7) 1.000
 ANA (<40/40/80/>80) 14/15/18/59 2/2/6/5 0.274
 AMA positivity 13 (12.3) 0 (0) 0.366
Splenomegaly 32 (30.8) 9 (60.0) 0.038
 Fibrosis stage (F0-F2/F3-F4) 55/42 5/4 1.000
Continuous traits Median (Min-Max) Median (Min-Max) P-value
 Age (years) 57 (9–87) 64 (46–85) 0.167
Total bilirubin (mg/dL) 1.1 (0.4–30.4) 5.1 (0.8–33.2) 0.001
 Aspartate aminotransferase (U/L) 248 (21–2738) 133 (46–1130) 0.229
 Alanine aminotransferase (U/L) 310 (15–2325) 284 (30–741) 0.429
Alkaline phosphatase (U/L) 456 (131–1463) 564 (420–830) 0.007
 Gamma-glutamyl transpeptidase (IU/L) 161 (26–679) 192 (48–1404) 0.532
Prothrombin time (%) 86 (29–130) 73 (43–109.1) 0.002
Albumin (g/dL) 3.8 (1.9–4.7) 3.2 (2.7–4.0) 0.004
Platelets (x 104/μL) 18.0 (8.9–39.6) 11.1 (6.8–36.8) 0.016
 Immunoglobulin G (mg/dL) 2536 (938–6750) 2163(1654–5495) 0.514
 Immunoglobulin M (mg/dL) 135.5 (47–1720) 172.5 (52–321) 0.618
 AIH score (except for histology score) 14 (6–18) 13 (9–16) 0.748
 AIH score (including histology score) 18 (8–22) 17 (9–21) 0.284
  1. Bold-faced type shows statistically significant difference