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Table 5 Frequency and odds ratios (95 % CI) of mutations in SPINK1, CFTR, CTRC in the individual groups with acute pancreatitis and in the control group

From: Genetic mutations in SPINK1, CFTR, CTRC genes in acute pancreatitis

  No. SPINK1* 14/221 (6.3 %) OR * (95 % CI) P value CFTR** 5/221 (2.3 %) OR (95 % CI) P value CTRC** 4/221 (1.8 %) OR (95 % CI) P value
Severity of the course
Mild AP 144 6 (4.2 %) 2.05 (0.85-5.1) P < 0.005 4 (2.8 %) 0.59 (0.16- 1.80) NS 2 (1.4 %) 1.57 (0.29-8.52) NS
Moderate AP 39 7 (17.9 %) 8 (10.4 %) 0 2 (1.4 %) 1,4 %
Severe AP 38 1 (2.6 %) 1 (2.6 %) 1 (2.6 %)
Etiology of AP
Alcohol 70 5 (7.1 %) 2.33 (0.61- 7.57) NS 1 (1.4 %) 0.37 (0.01-2.55) NS 2 (2.9 %) 2.50 (0.22- 17.84) NS
Gallstones 81 5 (6.2 %) 1.99 (0.53- 6.45) 3 (3.7 %) 0.98 (0.18- 3.7) 2 (2.5 %) 2.15 (0.19-15.33)
Idiopathic 63 4 (6.3) 2.05 (0.46- 7.23) 0 0 (0–1.78) 0 0 (0–8.365)
Cancer 7 0 0 (0–23.88) 1 (14.3 %) 4.2 (20.09- 39.08) 0 0 (0–85.65)
Reccurrences of AP
Yes 82 5 (6.1 %) 1.97 (0.52- 6.37) NS 1 (1.2 %) 0.32 (0.01- 2.16) NS 2 (2.4 %) 2.13 (0.19- 15.135) NS
No 139 9 (6.5 %) 2.10 (0.75- 5.72) 4 (2.9 %) 0.76 (0.18- 2.51) 2 (1.4 %) 1.24 (0.111-8.8
Control group 345 11 (3.2 %)* 13 (3.8 %)** 4 (1.2 %)**
  1. Indicates that the odds of SPINK1 mutations are 2.05 times higher in the AP group than in the control group. The limits (0.847; 5.096) for OR 95 % confidence interval are not very wide, so the OR estimate has rather good precision. The association between the group and the SPINK1mutations occurrence is not significant at the 0.05 level because 95 % confidence interval for the OR contains 1. However, right-sided F exact test rejects the null hypothesis that OR = 1 in favour of the alternative hypothesis that true odds ratio is higher than 1 (p = 0.0466). This means that the odds of SPINK1 in the AP group are higher than in the control group, and this conclusion is statistically significant at the 0.05 level
  2. NS no statistical significance
  3. *SPINK1 mutation in the acute pancreatitis group (AP) is more frequent than in the control group: p < 0.005
  4. **The differences between the CFTR, CTRC mutations in the acute pancreatitis group (AP) and in the control group are insignificant