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Table 2 Kinetic parameters of Na-glutamine co-transport in crypt cell BBMV

From: Mast cell regulation of Na-glutamine co-transporters B0AT1 in villus and SN2 in crypt cells during chronic intestinal inflammation

  V max (nmol/mg protein•6 sec) K m (mM)
Control 2.4 ± 0.9 49.6 ± 4.8
Inflamed 2.6 ± 0.4 21.2 ± 4.3*
Inflamed + ketotifen 2.3 ± 0.6 45 ± 0.6*
  1. In crypt cells, the affinity (K m ) of Na-glutamine co-transport which was increased significantly during chronic intestinal inflammation was reversed back to its normal levels by ketotifen treatment (n = 3, *p < 0.01).