Skip to main content

Table 2 Comparison of postoperative outcomes between probiotics and control (Intention-to-treat)

From: Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double-center and double-blind randomized clinical trial

Outcomes Intention-to-treat
Control (n = 68) PRO (n = 66) P Value
Septicemia incidence (%) 88 (60/68) 59 (39/66) 0.008
ALT (U/L) 56.20 ± 18.16 36.28 ± 18.92 <0.001
AST (U/L) 45.62 ± 22.68 36.18 ± 21.52 0.015
Intro-abdominal drainage time (d) 4.2 ± 1.6 4.6 ± 1.8 0.176
Incision infection (%) 12 (8/68) 9 (6/66) 0.779
Central lines infection (%) 9 (6/68) 11 (7/66) 0.777
Pneumonia infection (%) 12 (8/68) 9 (6/66) 0.097
Urinary infection (%) 13 (9/68) 2 (1/66) 0.017
First defecation time (d) 3.6 ± 1.8 2.8 ± 1.6 0.007
Diarrhea incidence (%) 46 (31/68) 24 (16/66) 0.012
Urinary catheters time (d) 7.1 ± 2.6 6.6 ± 2.8 0.286
Abdominal cramping (%) 49 (33/68) 23 (15/66) 0.017
Abdominal distension (%) 51 (35/68) 33 (22/66) 0.038
Intake time of fluid diet (d) 3.6 ± 1.2 3.2 ± 1.8 0.131
Intake time of solid diet (d) 5.2 ± 1.6 4.9 ± 1.6 0.280
Side effects of probiotic use 0 0 N/A
Duration of postoperative pyrexia (>38.5°C) (d) 6.98 ± 2.22 6.02 ± 1.68 0.006
Hypoalbuminemia (%) 47 (32/68) 27 (18/66) 0.021
Cumulative duration of antibiotic therapy 7.56 ± 2.26 6.22 ± 1.96 <0.001
Postoperative hospital stay 12.96 ± 3.06 11.26 ± 2.52 <0.001
Hospital charge (Yuan) 58262.36 ± 10262.36 52261.16 ± 12168.28 0.002
Death case 0 0 N/A
Serum zonulin (ng/mg protein) 1.36 ± 0.50 0.42 ± 0.36 <0.001
  1. ALT, alanine transarninase (normal value, 0–40 U/L); AST, aspartate aminotransferase (normal value, 0–40 U/L).