Table 2 General features and serum biochemical analyses in rats fed with choline-deficient L-amino acid defined (CDAA) diet receiving fluvastatin (Flu) or vehicle treatment compared with normal controls

Numbers

4

8

8

8

4

8

8

8

Steatosis score

0.00 ± 0.00

3.00 ± 0.00 ^**

3.00 ± 0.00 ^**

2.70 ± 0.95 ^**

0.00 ± 0.00

3.00 ± 0.00 ^**

3.00 ± 0.00 ^**

2.25 ± 1.17 ^#

Hepatocyte ballooning

0.0 ± 0.0

2.0 ± 0.0 ^**

2.0 ± 0.0 ^**

2.0 ± 0.0 ^**

0.0 ± 0.0

2.0 ± 0.0 ^**

2.0 ± 0.0 ^**

1.5 ± 0.8 ^**

Inflammation

0.00 ± 0.00

0.60 ± 0.52

0.80 ± 0.42 ^**

0.40 ± 0.52

0.00 ± 0.00

1.17 ± 0.25 ^**

1.60 ± 0.39 ^**

1.0 ± 0.55 ^**,†

Fibrosis score

0.00 ± 0.00

1.80 ± 0.42 ^**

1.20 ± 0.42 ^{# #}

0.70 ± 0.48^{# #, †}

0.00 ± 0.00

1.67 ± 0.56 ^**

1.15 ± 0.63 ^**

0.58 ± 0.92 ^#

BW (g)

312 ± 7

245 ± 9 ^**

217 ± 6 ^**

195 ± 8 ^**##

467 ± 10

442 ± 12

419 ± 7 ^**

399 ± 7 ^**#

LW (g)

10.9 ± 0.4

18.1 ± 0.9 ^**

14.7 ± 0.9 ^{** #}

14.3 ± 0.4 ^**##

14.3 ± 0.6

23.5 ± 0.9 ^**

20.3 ± 0.7 ^**

18.2 ± 1.8 ^##

AST (U/L)

96 ± 13

503 ± 89 ^*

439 ± 90 ^*

366 ± 72

77 ± 4

373 ± 30 ^**

311 ± 26 ^**

267 ± 49 ^**

ALT (U/L)

25 ± 2

134 ± 28 ^*

160 ± 25 ^**

121 ± 20

25 ± 5

161 ± 16 ^**

125 ± 11 ^**

84 ± 24 ^##

Cr (mg/dL)

0.43 ± 0.02

0.51 ± 0.05

0.48 ± 0.03

0.47 ± 0.04

0.40 ± 0.00

0.42 ± 0.01

0.44 ± 0.02

0.41 ± 0.01

TG (mg/dL)

47.5 ± 5.3

22.9 ± 1.9 ^**

26.4 ± 2.79 ^**

29.7 ± 4.7 ^*

58 ± 9

30 ± 4 ^*

24 ± 3 ^*

41 ± 7

Cholesterol (mg/dL)

69.0 ± 4.4

56.4 ± 1.9

56.3 ± 2.3

60.7 ± 4.4

63 ± 6

55 ± 2

57 ± 2

58 ± 4

Glucose (mg/dL)

158 ± 9

124 ± 6

132 ± 11

126 ± 10

134 ± 12

123 ± 5

127 ± 6

132 ± 3

TNFα (pg/mL)

50 ± 4

109 ± 12 ^**

67 ± 11 ^##

64 ± 9 ^##

35 ± 7

55 ± 22 ^*

30 ± 11 ^##

11 ± 3 ^#