Stromal expression of miR-21 in T3-4a colorectal cancer is an independent predictor of early tumor relapse

BMC Gastroenterology

Table 1 Correlations of clinicopathological parameters and expression of miR-21 in 277 patients with T3-4a colorectal cancer

Parameter	N	miR-21 expression		p-value
Parameter	N	High	Low	p-value
Age
<65	139	36 (25.9%)	103 (74.1%)	0.565
≥65	138	40 (29.0%)	98 (71.0%)
Gender
Male	181	51 (28.2%)	130 (71.8%)	0.705
Female	96	25 (26.0%)	71 (74.0%)
Primary site
Right colon	82	20 (24.4%)	62 (75.6%)	0.636
Left colon	91	28 (30.8%)	63 (69.2%)
Rectum	104	28 (26.9%)	76 (73.1%)
Histologic type
Non-mucinous	262	73 (27.9%)	189 (72.1%)	0.767
Mucinous	15	3 (20.0%)	12 (80.0%)
Differentiation
Well or moderately	260	74 (28.5%)	186 (71.5%)	0.168
Poorly	17	2 (11.8%)	15 (88.2%)
Depth of invasion
pT3	228	65 (28.5%)	163 (71.5%)	0.388
pT4a	49	11 (22.4%)	38 (77.6%)
Lymph node metastasis
Absent	138	39 (28.3%)	99 (71.7%)	0.759
Present	139	37 (26.6%)	102 (73.7%)
AJCC stage				0.118
IIA	122	34 (27.9%)	88 (72.1%)
IIB	16	5 (31.2%)	11 (68.8%)
IIIB	82	28 (34.1%)	54 (65.9%)
IIIC	57	9 (15.8%)	48 (84.2%)
Perineural invasion
Absent	219	58 (26.5%)	161 (73.5%)	0.490
Present	58	18 (31.0%)	40 (69.0%)
Lymphatic invasion
Absent	120	33 (27.5%)	87 (72.5%)	0.984
Present	157	43 (27.4%)	114 (72.6%)
Vascular invasion
Absent	255	72 (28.2%)	183 (71.8%)	0.311
Present	22	4 (18.2%)	18 (81.8%)
CEA (ng/dL)^a
<5	163	46 (28.2%)	117 (71.8%)	0.542
≥5	78	25 (32.1%)	53 (67.9%)
Adjuvant therapy
No	16	1 (6.2%)	15 (93.8%)	0.079
Yes	261	75 (28.7%)	186 (71.3%)
E-cadherin
Low	109	40 (36.7%)	69 (63.3%)	0.019
High	161	37 (23.0%)	124 (77.0%)
MTA1
Low	168	37 (22.0%)	131 (78.0%)	0.004
High	102	39 (38.2%)	63 (61.8%)

^aPreoperative serum level of carcinoembryonic antigen (CEA) was measured in 241 colorectal cancer patients. AJCC, American Joint Committee on Cancer. Immunohistochemistry for E-cadherin and MTA1 was available in 270 cases.

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