Skip to main content

Table 1 Subject characteristics and univariate logistic regression analysis of factors associated with non-adherence (N = 429)

From: A screening instrument to identify ulcerative colitis patients with the high possibility of current non-adherence to aminosalicylate medication based on the Health Belief Model: a cross-sectional study

  n (%) or Mean ± SD 1 OR 2 95% CI 3 p value
Beliefs about taking aminosalicylates      
Susceptibility [0-4] 1.5 ± 0.9 1.61 1.28–2.02 <0.01
Severity [0-4] 0.7 ± 1.0 2.22 1.78–2.75 <0.01
Benefits [0-8] 2.5 ± 1.7 1.32 1.17–1.49 <0.01
Barriers [0-48] 21.3 ± 9.9 1.11 1.07–1.13 <0.01
Cues to action [0-12] 4.6 ± 2.7 1.20 1.10–1.30 <0.01
Disease characteristics      
Duration of UC: Less than 5 years [more than 5 years] 143 (33.4) 1.20 0.76–1.86 0.44
Family history: Absence [presence] 409 (95.3) 0.98 0.37–2.61 0.96
The duration of current remissiona: More than 3 months [less than 3 months] 330 (77.3) 1.57 0.92–2.66 0.09
Disease region by recent colonoscopyb: Rectum [total, left-side] 113 (26.4) 1.54 0.98–2.43 0.06
Medication characteristics      
Aminosalicylates      
  Type of aminosalicylatesc: Mesalazine [salazosulfapyridine] 130 (32.8) 1.02 0.64–1.61 0.94
  Times of day at which the drugs were taken: 278 (64.8) 1.14 0.74–1.77 0.55
2 times or less [3 times or more]
  Number of tablets/day: 8 tablets or less [9 tablets or more] 216 (50.3) 1.79 1.18–2.73 <0.01
  Prescribed dose (g/day) 3.5 ± 0.9 0.75 0.59–0.95 0.02
Current concomitant therapy      
  Topical aminosalicylates: Absence [presence] 301 (70.2) 1.11 0.70–1.75 0.66
  Oral corticosteroids: Absence [presence] 404 (94.2) 2.30 0.77–6.84 0.13
  Topical corticosteroids: Absence [presence] 395 (92.1) 1.68 0.71–3.97 0.23
  Thiopurines: Absence [presence] 369 (86.0) 2.32 1.14–4.39 0.02
  Calcineurin inhibitors: Absence [presence] 410 (95.6) 1.19 0.42–3.37 0.78
  Leukocyte apheresis: Absence [presence] 421 (98.1) 1.27 0.25–6.36 0.77
  Biologics: Absence [presence] 403 (93.9) 2.41 0.82–7.16 0.11
Abdominal symptoms      
  Stool consistency: Formed [liquid] 375 (87.4) 0.99 0.53–187 0.99
  Bowel movements/day: 3 times or less [4 times or more] 178 (41.5) 1.22 0.80–1.85 0.36
  Urgency: Absence [presence] 239 (55.7) 1.21 0.80–1.85 0.37
  Pain: Absence [presence] 288 (67.1) 0.89 0.58–1.38 0.61
  Visible bleeding: Absence [presence] 313 (73.0) 1.65 1.003–2.71 0.04
Sociodemographic characteristics      
Gender: Male [female] 243 (56.6) 0.87 0.58–1.33 0.53
Age 39.9 ± 12.5 0.99 0.97–1.01 0.27
Employment: Full time job, family-operated business [part time job, student, housewife, unemployed] 243 (56.6) 1.32 0.87–2.02 0.19
Marital status: Married [unmarried, divorced, widowed] 251 (41.5) 0.92 0.60–1.41 0.71
Educational level: Junior high school, high school, vocational school, junior college [college or higher] 207 (48.2) 0.93 0.61–1.40 0.71
Living situation: Living alone [living with someone] 68 (15.9) 1.14 0.65–1.98 0.65
Hospital      
  Hospital B [A] 239 (55.7) 1.10 0.65–1.85 0.72
  Hospital C [A] 87 (20.3) 1.72 0.93–3.19 0.10
  1. Information in [brackets] are reference categories.
  2. an = 427, bn = 428, cn = 397 (32 subjects were prescribed two kinds of aminosalicylates and not included in this analysis).
  3. 1SD: standard deviation, 2OR: odds ratio, 3CI: confidence interval.