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Table 6 Pooled analysis of studies exploring the role of TLR4 Thr399Ile in IBD

From: Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms: New data and a meta-analysis

Study Sample size Cases (Events/Total) Controls (Events/Total) Odds 95% CI P value
Torok et al. 2004 [ [33]] IBD: 200 38/400 12/290 2.432 1.24 to 4.74  
HC: 145
Gazouli et al. 2005 [ [36]] IBD: 205 4/410 2/200 0.975 0.17 to 5.37  
HC: 100
Oostenbrug et al. 2005 [ [37]] IBD: 721 93/1442 29/598 1.353 0.88 to 2.07  
HC: 299
Zouiten-Mekki et al. 2009 [ [40]] IBD: 120 15/240 8/160 1.267 0.52 to 3.06  
HC: 80
Browning et al. 2007 [ [42]] IBD: 794 106/1588 46/832 1.222 0.85 to 1.74  
HC: 416
De Ridder et al. 2007 [ [23]] IBD: 707 106/1414 22/488 1.717 1.07 to 2.75  
HC: 244
Rigoli et al. 2008 [ [45]] IBD: 178 12/356 6/206 1.163 0.43 to 3.14  
HC: 103
Manolakis et al. 2013 [ [46]] IBD: 350 61/700 33/548 1.490 0.96 to 2.31  
HC: 274
Our study 2014 IBD: 117 10/234 3/224 3.289 0.89 to 12.11  
HC: 112
Total (fixed effects)   445/6784 161/3546 1.479 1.22 to 1.82 0.0001
Total (random effects)   445/6784 161/3546 1.465 1.21 to 1.80