Figure 6

Liver regeneration as evaluated by [ ³ H]-thymidine incorporation into hepatic DNA in 60-70% partially hepatectomized rats and AS-19. Time course of liver regeneration as evaluated by [³H]-thymidine incorporation into DNA in 60-70% partially hepatectomized rats having received intraperitoneally saline (group A) or SB-258719 (4 mg/kg bodyweight) 16 h after partial hepatectomy (group E) or SB-258719 (4 mg/kg bodyweight) followed by intraperitoneal administration of AS-19 (10 mg/kg bodyweight) 16.5 h after partial hepatectomy (group G). Results represent the findings from at least five rats killed at 8, 18, 20, 24, 32, 40, 48, 60 and 72 h (group A) and at 18, 20, 24, 32, 40, 48, 60 and 72 h (groups E and G). DNA group E vs group G; P < 0.001: 18–40 h.