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Table 1 Laennec scoring system for staging fibrosis in liver specimens

From: Effect of bone marrow-derived mesenchymal stem cells on hepatic fibrosis in a thioacetamide-induced cirrhotic rat model

Stage Name Septa (thickness and number) Criteria Score
0 No definite fibrosis    0
1 Minimal fibrosis +/- No septa or rare thin septum; may have portal expansion or mild sinusoidal fibrosis 1
2 Mild fibrosis + Occasional thin septa; may have portal expansion or mild sinusoidal fibrosis 2
3 Moderate fibrosis ++ Moderate thin septa; up to incomplete cirrhosis 3
4A Mild, definite, or probable cirrhosis +++ Marked septation with rounded contours or visible nodules. Most septa are thin (one broad septum allowed) 4
4B Moderate cirrhosis ++++ At least two broad septa, but not very broad septa and less than half of biopsy length composed of minute nodules 5
4C Severe cirrhosis +++++ At least one very broad septum or more than half of biopsy length composed of minute nodules (micronodular cirrhosis) 6