Osteoporosis increases subsequent risk of gallstone: a nationwide population-based cohort study in Taiwan

BMC Gastroenterology

Table 3 Overall and age- and sex-specific incidence densities and relative hazard of gallstone in the osteoporosis and comparison cohorts

Factor	Osteoporotic group				Comparative group				Crude HR	Adjust HR
Factor	Incident cases	Person-years	ID ¹	95% CI	Incident cases	Person-years	ID ¹	95% CI
Age (y)^a
50-64	42	3080.05	13.64	9.54 - 17.73	103	12702.40	8.11	6.55 - 9.67	1.68 (1.17 - 2.40)**	1.56 (1.06 - 2.28)*
65-79	60	3846.65	15.60	11.68 - 19.51	170	15720.01	10.81	9.20 - 12.43	1.44 (1.07 - 1.94)*	1.25 (0.92 - 1.71)
≥ 80	12	868.91	13.81	6.05 - 21.57	38	3544.48	10.72	7.33 - 14.11	1.28 (0.67 - 2.46)	1.31 (0.64 - 2.68)
Sex^b
Men	17	1142.92	14.87	7.86 - 21.89	48	4719.56	10.17	7.31 - 13.03	1.46 (0.84 - 2.54)	1.09 (0.60 - 1.96)
Women	97	6652.69	14.58	11.70 - 17.46	263	27247.33	9.65	8.49 - 10.81	1.51 (1.20 - 1.91)**	1.40 (1.09 - 1.79)**
Total	114	7795.61	14.62	11.96 - 17.29	311	31966.89	9.73	8.65 - 10.80	1.50 (1.21 - 1.86)***	1.35 (1.07 - 1.69)*

*p <0.05,**p <0.01, ***p <0.001.
HR, hazard ratio; ID, incidence density (per 1000 patient-years); CI, confidence interval.
¹Based on the Poisson assumption.
^aAdjusted for sex, age, monthly income, region, urbanization level, hypertension, hyperlipidemia, diabetes, cirrhosis, spinal cord injury, hormone replacement, and clofibrate.
^bAdjusted for age, monthly income, region, urbanization level, hypertension, hyperlipidemia, diabetes, cirrhosis, spinal cord injury, hormone replacement, and clofibrate.

ISSN: 1471-230X