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Table 2 Genotype frequencies of TGFB1 and VEGF polymorphism gastric cancer cases and controls and their associations with risk of gastric cancer

From: The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer

 

Cases (n = 171)

Controls (n = 353)

    

Genotypes

n

%

n

%

P †

Crude OR

(95% CI)

Adjusted OR (95% CI) *

P ‡

TGFB1 -509 C >T (rs1800469)

  

0.404

   

   CC

125

73.1

238

67.4

 

1.00

1.00

 

   CT

33

19.3

80

22.7

 

0.79 (0.50-1.24)

0.81 (0.51-1.30)

0.386

   TT

13

7.6

35

9.9

 

0.71 (0.36-1.39)

0.71 (0.36-1.40)

0.323

   CT+TT

46

26.9

115

32.6

 

0.76 (0.51-1.14)

0.78 (0.52-1.18)

0.239

   C allele

0.173

0.212

0.246**

   

TGFB1 869 T >C (rs1800470)

  

0.805

   

   TT

57

33.3

111

31.4

 

1.00

1.00

 

   CT

83

48.5

170

48.2

 

0.95 (0.63-1.44)

1.01 (0.67-1.55)

0.947

   CC

31

18.1

72

20.4

 

0.84 (0.49-1.42)

0.81 (0.48-1.39)

0.448

   CT+CC

114

66.7

242

68.6

 

1.16 (0.73-1.85)

0.92 (0.62-1.35)

0.374

   C allele

0.424

0.445

0.727**

   

TGFB1 915 G >C (rs1800471)

  

0.447

   

   GG

151

88.3

313

88.7

 

1.00

1.00

 

   CG

18

10.5

39

11.0

 

0.96 (0.53-1.73)

0.99 (0.54-1.83)

0.994

   CC

2

1.2

1

0.3

 

4.15 (0.37-46.1)

4.91 (0.43-56.3)

0.201

   CG+CC

20

11.7

40

11.3

 

1.04 (0.59-1.83)

1.09 (0.56-1.96)

0.776

   C allele

0.064

0.058

0.715**

   

VEGF -1498T > C (rs833061)

  

0.748

   

   TT

51

29.8

111

31.4

 

1.00

1.00

 

   CT

83

48.6

159

45.0

 

1.14 (0.74-1.74)

1.12 (0.73-1.74)

0.597

   CC

37

21.6

83

23.6

 

0.97 (0.58-1.62)

0.99 (0.59-1.67)

0.973

   CC+CT

120

70.2

242

68.6

 

1.08 (0.73-1.61)

1.08 (0.72-1.62)

0.715

   C allele

0.459

0.460

0.984**

   

VEGF -634G > C (rs2010963)

  

0.006

   

   GG

69

40.4

51.0

  

1.00

1.00

 

   CG

72

42.1

28.0

  

1.90 (1.26-2.86)

1.88 (1.24-2.86)

0.003

   CC

30

17.5

21.0

  

1.06 (0.64-1.76)

1.10 (0.66-1.85)

0.712

   CG+CC

102

59.6

49.0

  

1.54 (1.06-2.23)

1.56 (1.07-2.27)

0.022

   C allele

0.386

0.349

0.491**

   

VEGF +936C > T (rs3025039)

  

0.550

   

   CC

127

74.3

78.2

  

1.00

1.00

 

   CT

41

24.0

19.8

  

1.27 (0.82-1.97)

1.29 (0.83-2.02)

0.262

   TT

3

1.8

2.0

  

0.93 (0.24-3.66)

1.12 (0.28-4.58)

0.837

   CC+CT

44

25.8

21.8

  

1.24 (0.81-1.90)

1.28 (0.83-1.97)

0.269

   T allele

0.137

0.119

0.481**

   
  1. * Adjusted for age, gender, ethnicity, smoking status and alcohol status in a logistic regression model.
  2. †Two-sided χ 2 test for either genotype distribution or allele frequency.
  3. ‡ Two-sided χ 2 test for difference in frequency distribution of genotype between cases and controls by adjusted for age, gender, ethnicity, smoking status and alcohol status.
  4. ** Two-sided χ 2 tests for the differences in the minor allele frequencies between cases and controls
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BMC Gastroenterology

ISSN: 1471-230X

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