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Table 1 Development of metaplasia and squamous cell carcinoma in mouse esophagus due to gastroesophageal reflux

From: Gastroesophageal reflux leads to esophageal cancer in a surgical model with mice

    Week 20 Week 40 Week 80
Group Genotype Treatment Metaplasia Metaplasia Squamous cell carcinoma Squamous cell carcinoma
A Wild-type Non-operated control 0/10 0/10 0/10 -
B Wild-type Reflux surgery and
50 mg/kg/m Fe, i.p. (Wk 41 to 80)
1/20
(5%)
6/37
(16.2%)
0/37 12/13
(92.3%)
C p53 A135V Reflux surgery 1/19
(5.3%)
2/42
(4.8%)
0/42 -
D INK4a/Arf +/- Reflux surgery 0/10 0/14 1/14
(7.1%)
-
E Wild-type Reflux surgery, omeprazole (1,400 ppm) and 50 mg/kg/m Fe, i.p. (Wk 21 to 40) - 0/11 0/11  
F Wild-type Reflux surgery and
50 mg/kg/m Fe, i.p. (Wk 2 to 40)
- 0/22 0/22 -
G Wild-type Reflux surgery, gastrectomy and
50 mg/kg/m Fe, i.p. (Wk 2 to 40)
- 1/14
(6.7%)
3/14a
(21.4%)
-
  1. a Compared with Group B (P < 0.05)