Table 1 Development of metaplasia and squamous cell carcinoma in mouse esophagus due to gastroesophageal reflux

A

Wild-type

Non-operated control

0/10

0/10

0/10

-

B

Wild-type

Reflux surgery and

50 mg/kg/m Fe, i.p. (Wk 41 to 80)

1/20

(5%)

6/37

(16.2%)

0/37

12/13

(92.3%)

C

p53 ^A135V

Reflux surgery

1/19

(5.3%)

2/42

(4.8%)

0/42

-

D

INK4a/Arf ^+/-

Reflux surgery

0/10

0/14

1/14

(7.1%)

-

E

Wild-type

Reflux surgery, omeprazole (1,400 ppm) and 50 mg/kg/m Fe, i.p. (Wk 21 to 40)

-

0/11

0/11

F

Wild-type

Reflux surgery and

50 mg/kg/m Fe, i.p. (Wk 2 to 40)

-

0/22

0/22

-

G

Wild-type

Reflux surgery, gastrectomy and

50 mg/kg/m Fe, i.p. (Wk 2 to 40)

-

1/14

(6.7%)

3/14^a

(21.4%)

-