Figure 4

Effect of lafutidine (30 mg/kg) and cimetidine (10 mg/kg), relative to vehicle, on (A) intragastric acidity and (B) weight of gastric content measured 60 and 120 min after exposure of the stomach to HCl (0.25 M) and expressed as a percentage of the respective values measured immediately after gastric acid loading (0 min). Lafutidine, cimetidine or vehicle was administered by gastric gavage 30 min before administration of HCl. The values represent means + SEM, n = 8. ** P ≤ 0.05 versus time 0 min under the same treatment, + P ≤ 0.1, ++ P ≤ 0.05 versus time 60 min under the same treatment, °P ≤ 0.1, °°P ≤ 0.05 versus vehicle at the same time point post-HCl.