Table 2 Performance of the biomarkers for the diagnosis of cholangiocarcinoma
From: Detection of serum MMP-7 and MMP-9 in cholangiocarcinoma patients: evaluation of diagnostic accuracy
Biomarker (cut-off value) | Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | PLR (95% CI) | NLR (95% CI) |
|---|---|---|---|---|
CEA (3 ng/ml) | 70.73 (55.52–82.39) | 43.75 (28.17–60.67) | 1.26 (0.87–1.81) | 0.67 (0.36–1.24) |
CEA (5 ng/ml) | 58.54 (43.37–72.24) | 62.50 (45.25–77.07) | 1.56 (0.93–2.62) | 0.66 (0.42–1.04) |
CA19-9 (35 U/ml) | 81.82 (68.04–90.49) | 48.48 (32.50–64.78) | 1.59 (1.11–2.27) | 0.38 (0.18–0.77) |
CA19-9 (100 U/ml) | 70.45 (55.78 – 81.84) | 63.64 (46.62–77.81) | 1.94 (1.19–3.16) | 0.46 (0.28–0.78) |
MMP-9 (15.0 ng/ml) | 63.64 (48.87–76.22) | 41.94 (26.42–59.23) | 1.67 (0.93–3.01) | 0.59 (0.35–0.98) |
MMP-9 (20.0 ng/ml) | 34.10 (21.88–48.86) | 74.19 (56.75–86.30) | 1.32 (0.64–2.73) | 0.89 (0.66–1.20) |
MMP-7 (6.0 ng/ml) | 76.32 (60.79–87.01) | 46.88 (30.87–63.55) | 1.44 (0.99–2.08) | 0.51 (0.26–1.00) |
MMP-7 (7.4 ng/ml) | 63.16 (47.28–76.62) | 71.88 (54.63–84.44) | 2.25 (1.23–4.11) | 0.51 (0.32–0.82) |