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Table 7 Sensitivity analyses of NashTest for the diagnosis of Borderline Nash or Nash versus No Nash [Area under the ROC curves (AUROCs)], according to group, ALT values, alcohol consumption, quality of biopsy, inclusion of patients without steatosis, and exclusion of high risk of biomarkers failures.

From: Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease

Characteristic of patients n NashTest AUROC Lower 95% Upper 95% Prevalence Borderline or NASH Significance
All 257 patients 257 0.78 0.72 0.84 0.38  
Stratified according to Group*       
Training Group 160 0.77 0.68 0.84 0.36 0.34
Validation Group 97 0.83 0.67 0.90 0.42  
Stratified according to ALT value*       
ALT< 50IU/L 92 0.74 0.62 0.82 0.50 0.24
ALT>= 50 IU/L 165 0.81 0.73 0.87 0.32  
Stratified according to Alcohol consumption*       
None 95 0.78 0.67 0.86 0.37 0.83 and 0.20
< 30 g for men and < 20 g for female 150 0.77 0.66 0.84 0.39 0.83 and 0.19
>= 30 g for men or >= 20 g for female 12 1.00 0.35 1.00 0.33 0.20 and 0.19
Stratified according to Quality of biopsy*       
< 25 mm 194 0.78 0.71 0.84 0.39 0.98
>= 25 mm 63 0.78 0.63 0.88 0.37  
Fragmented 148 0.77 0.68 0.84 0.36 0.46
Not Fragmented 109 0.81 0.71 0.88 0.40  
Patients included or excluded       
Patients without steatosis included** 272 0.79 0.72 0.84 0.39 0.83
High risk of NashTest failures excluded**       
Gilbert excluded 244 0.78 0.71 0.83 0.39 0.97
Acute Inflammation excluded 254 0.78 0.72 0.84 0.38 0.98
  1. * Comparison between stratified groups
  2. ** Comparison with all 257 patients