Table 4 Prognostic analysis of DFS and OS for GISTs of the small intestine in terms of immunohistochemical features
Variable | Mean DFS (ms; 95%CI of mean) | P | Mean OS (ms; 95%CI of mean) | P | |
|---|---|---|---|---|---|
CD117 (KIT) | Focally positive (N = 12) | 40.1 (18.3–61.9) | 0.1276 | 77.8 (39.9–115.6) | 0.2159 |
Diffusely positive (N = 73) | 74.4 (54.0–94.7) | 101.6 (79.1–124.3) | |||
KIT immunopattern | Diffuse cytoplasmic stain (N = 55) | 80.8 (54.6–107.0) | 0.0981 | 95.5 (70.9–120.1) | 0.8628 |
Mixed with "golgi pattern" (N = 30) | 51.6 (33.1– 70.1) | 99.4 (69.1–129.7) | |||
CD34 | Negative (N = 25) | 64.8 (44.9–84.6) | 0.4806 | 87.5 (64.7–110.4) | 0.2242 |
Focally positive (N = 28) | 55.9 (34.6–77.2) | 70.6 (48.2–93.0) | |||
Diffusely positive (N = 32) | 81.0 (50.6–111.4) | 116.9 (84.4–149.2) | |||
SMA | Negative (N = 36) | 76.3 (44.4–108.3) | 0.1866 | 101.2 (70.5–132.0) | 0.0637 |
Focally positive (N = 17) | 45.4 (24.3– 66.5) | 56.8 (34.6–78.9) | |||
Diffusely positive (N = 32) | 82.0 (60.7–103.2) | 106.8 (82.2–131.4) | |||
S-100 | Negative (N = 34) | 81.9 (49.9–113.9) | 0.1274 | 104.9 (75.8–133.9) | 0.3896 |
Focally positive (N = 31) | 64.5 (44.6–84.5) | 79.8 (60.6–99.0) | |||
Diffusely positive (N = 20) | 48.4 (22.43–74.3) | 78.6 (43.4–113.9) | |||
Ki-67 index | < 10% (N = 80) | 73.6 (53.9–93.4) | 0.0014 | 99.4 (78.5–120.2) | 0.0171 |
≧10% (N = 5) | 13.8 (6.8–20.8) | 24.0 (13.0–35.0) |