Figure 2

RRV infection induces biliary inflammation in livers of IL-12KO mice. Infection of IL-12KO mice with RRV leads to minimal portal changes when compared to saline-injected mice and RRV-infected wild-type (WT) within 3 days (panels A, B, C). In contrast, RRV induces a remarkable portal expansion at 7 and 14 days in both IL-12KO and WT mice (panels E, F, H, I). Although the portal expansion has the same extent in both genotypes, IL12-KO livers have a mixed cellular infiltration with a predominance of neutrophils, while the portal spaces of WT livers contain primarily lymphocytes (insets in panels E, F, H, I). Arrows point to extramedullary hematopoiesis at day 3; N = 15–20 mice in each group; scale bar (left upper portion of each panel): 100 μ.