Figure 1

CK and AdK activities in pathological and normal liver tissue. Specific CK (A) and AdK activities (B) in total homogenate fractions were determined as described under "Methods". The liver samples were classified into five groups: group 1 – cirrhotic liver tissue (nos. 5, 7, 11, 13, 17–19, 23, 24); group 2 – neoplastic tissues (nos. 4, 9, 14, 15, 20, 21; 2 primary hepatocellular carcinomas [nos. 4 and 9]; 3 cholangiocellular carcinomas [nos. 14, 20 and 21]; 1 liver metastasis of a malignant melanoma [no. 15]); group 3 – samples of necrotizing liver tissue due to acute or subacute organ rejection (nos. 2, 6, 22); group 4 – samples of macroscopically normal liver parenchymal tissue (nos. 3, 8, 10, 16, 25) surrounding focal liver pathologies (2 primary HCCs [nos. 4 and 9]; metastasis of malignant melanoma [no. 15]; vena hepatica occlusion [no. 24]); group 5 – samples originating from a normal rat liver (no. 12) and from a patient with steatosis hepatis (no. 1). No AdK activity measurements are available for liver sample no. 1.