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Table 1 International diagnostic criteria for diagnosis of AIH

From: Autoimmune hepatitis in India: profile of an uncommon disease

Parameter Score
Gender  
   Female +2
   Male 0
Serum biochemistry  
   Ratio of elevation of serum alkaline phosphatase vs. aminotransferase  
   >3.0 -2
   1.5–3 0
   <1.5 +2
Total serum globulin, γ-globulin, or IgG (times upper limit normal)  
   >2.0 +3
   1.5–2.0 +2
   1.0–1.5 +1
   <1.0 0
Autoantibodies (titers by immunofluorescence on rodent tissue)  
   ANA, SMA, or LKM-1  
>1:80 +3
1:80 +2
1:40 +1
<1:40 0
   Antimitochondrial antibodies  
Positive -4
Negative 0
Hepatitis viral markers  
   Negative +3
   Positive -3
Other etiological factors  
   History of drug usage  
Yes -4
No +1
   Alcohol (average consumption)  
<25 g/day +2
>60 g/day -2
   Genetic factors: HLA DR3 or DR4 +1
   Other autoimmune diseases +2
Response to therapy  
   Complete +2
   Relapse +3
Liver histology  
   Interface hepatitis +3
   Predominant lymphoplasmacytic infiltrate +1
   Rosetting of liver +1
   None of above -5
   Biliary changes -3
   Other changes -3
Seropositivity for other defined autoantibodies +2
  1. Definite AIH, >15 before treatment and >17 after treatment; probable AIH 10–15 before treatment and 12–17 after treatment