Table 1 International diagnostic criteria for diagnosis of AIH
From: Autoimmune hepatitis in India: profile of an uncommon disease
Parameter | Score |
|---|---|
Gender | Â |
   Female | +2 |
   Male | 0 |
Serum biochemistry | Â |
   Ratio of elevation of serum alkaline phosphatase vs. aminotransferase |  |
   >3.0 | -2 |
   1.5–3 | 0 |
   <1.5 | +2 |
Total serum globulin, γ-globulin, or IgG (times upper limit normal) |  |
   >2.0 | +3 |
   1.5–2.0 | +2 |
   1.0–1.5 | +1 |
   <1.0 | 0 |
Autoantibodies (titers by immunofluorescence on rodent tissue) | Â |
   ANA, SMA, or LKM-1 |  |
>1:80 | +3 |
1:80 | +2 |
1:40 | +1 |
<1:40 | 0 |
   Antimitochondrial antibodies |  |
Positive | -4 |
Negative | 0 |
Hepatitis viral markers | Â |
   Negative | +3 |
   Positive | -3 |
Other etiological factors | Â |
   History of drug usage |  |
Yes | -4 |
No | +1 |
   Alcohol (average consumption) |  |
<25 g/day | +2 |
>60 g/day | -2 |
   Genetic factors: HLA DR3 or DR4 | +1 |
   Other autoimmune diseases | +2 |
Response to therapy | Â |
   Complete | +2 |
   Relapse | +3 |
Liver histology | Â |
   Interface hepatitis | +3 |
   Predominant lymphoplasmacytic infiltrate | +1 |
   Rosetting of liver | +1 |
   None of above | -5 |
   Biliary changes | -3 |
   Other changes | -3 |
Seropositivity for other defined autoantibodies | +2 |