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Table 2 Symptom improvement or resolution by study, time point and treatment group

From: Are proton pump inhibitors the first choice for acute treatment of gastric ulcers? A meta analysis of randomized clinical trials

  

Improvement (%Resolved)

  

Study Drug

Comparator

Reference

Symptom

2 wks

4 wks

2 wks

4 wks

Dekkers [26]

Pain frequency

71 (34)1

82 (52)2

61 (29)1

65 (44)2

 

Day pain

88 (60)1

90 (75)2

75 (59)1

83 (67) 2

 

Night pain

82 (68)1

89 (84)2

79 (61)1

80 (68) 2

Witzel [25]

Pain free

79

88

68

81

Florent [24]

Daytime pain

 

863

 

603

 

Night pain

 

100

 

70

Bardhan [15]

Pain free

 

L30 = 75

 

65

   

L60 = 72

  

Michel [16]

Epigastric pain relief

 

73

 

72

Valenzuela [13]

Global assessment of GI symptoms

 

O40 = 49.3

  
   

O20 = 40.5

  

Ital Coop Grp [19]

Overall symptoms

75

87

65

80

 

Epigastric day pain

94

 

92

 
 

Epigastric night pain

96

 

91

 

Walan [20]

Ulcer symptoms free

O40 = 69

 

55

 
  

O20 = 62

   

Cloud [14]

Frequency of symptoms

 

Rab20=(64)2

 

(28)2

   

Rab40=(46)2

  
 

Severity of daytime symptoms

 

Rab20=(62)2

 

(54)2

   

Rab40=(57)2

  
 

Severity of nighttime symptoms

 

Rab20=(70)2

 

(65)2

   

Rab40=(55)2

  
  1. w = week, Rab = rabeprazole, L = lansoprazole, O = omeprazole. The number after the letter indicates the dose. 1: three weeks, 2: six weeks, 3: eight weeks.
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BMC Gastroenterology

ISSN: 1471-230X

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