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Table 3 List of steroid response genes screened in biomarker assay

From: Biomarkers can predict potential clinical responders to DIMS0150 a toll-like receptor 9 agonist in ulcerative colitis patients

Gene Name Gene ID Reference Sreening result
TLR9 Toll-like receptor 9 54106 19, 20 3
TSP-1 Thrombospondin-1 7057 19 5
TSP-2 Thrombospondin-2 7058 19 1
IDO Indoleamine 2,3-dioxygenase 1 3620 19 4
MARCO Macrophage receptor with collagenous structure 8685 19 4
IL-1β Interleukin 1, beta 3553 19 1
IL-1RI Interleukin-1 receptor type 1 3554 19 4
IL-1RII Interleukin-1 receptor type 2 7850 19, 21 5
IL-1Rα Interleukin-1 receptor antagonist 3557 19 3
IL-1RAP IL-1 receptor accessory protein 3556 20 3
IL-7Rα Interleukin 7 receptor, alpha 3575 19 1
IL-13Rα2 Interleukin-13 receptor subunit, alpha 2 3598 19 1
CD163 Antigen CD163 9332 19 5
GZMA Granzyme 1, serine esterase 3 3001 19 4
GILZ Glucocorticoid-induced leucine zipper 1831 19 1
CD49D Antigen CD49D; integrin alpha 4 3676 19 1
GRα Glucocorticoid nuclear receptor, isoform alpha 2908 5, 20 3
GRβ Glucocorticoid nuclear receptor, isoform beta 2908 19, 20 3
GRγ Glucocorticoid nuclear receptor, isoform gamma 2908 20 3
HSP90α Heat shock protein HSP 90, alpha 3320 22 2
HSP90β Heat shock protein HSP 90, beta 3326 22 2
UGT2 UDP glucuronosyltransferase 2 7362 23 2
IRS-1 Insulin receptor substrate 1 3667 23 4
FoxP3 Forkhead box protein P3 50943 24 4
CFL1 Cofilin 1 1072 25 1
HDAC2 Histone deacetylase 2 3066 26 1
IGFBP2 Insulin-like growth factor binding protein 2 3485 27 1
MDR1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 5243 4 1
VitD3R Vitamin D (1,25- dihydroxyvitamin D3) receptor 7421 17 1
FKBP51 FK506 binding protein 5 2289 28 3
GROα Growth-regulated gene-alpha 2919 29 3
VEGFA Vascular endothelial growth factor 7422 30 2
SGK Serum- and glucocorticoid-inducible protein kinase 6446 31 1
IFNγR1 Interferon gamma receptor 1 3459 32 1
  1. (1)Excluded because of too high individual variability in healthy volunteers.
  2. (2)Excluded because Dexamethasone (Dex) response in healthy volunteers was not reliable.
  3. (3)Excluded because difference in Dex response between steroid resistant patients and healthy volunteers was not reliable.
  4. (4)Excluded because of missing or not reliable synergistic effect when stimulated with Dex and DIMS0150.
  5. (5)Selected as potential biomarker because all four criteria were fulfilled (see text).