Table 1 KEGG pathways of significantly differentially methylated genes

Different between tumor and tumor-adjacent gastric tissue

Pathways in cancer

hsa05200

0.0000014

DCC, WNT5A, FGF5, RET, FGF8, FLT3, PPARG, TGFB3, FGF12, MMP2, GLI3, TGFB2, WNT2, SMO, CSF3R, HHIP, CCNA1, FGF2, FGF3

Hedgehog signaling pathway

hsa04340

0.0015474

WNT2, WNT5A, SMO, HHIP, GLI3, BMP6

Cytokine-cytokine receptor interaction

hsa04060

0.0019703

LIF, FLT1, FLT3, FLT4, IFNG, TGFB3, CSF3R, NGFR, KDR, TNFSF8, EPO, TGFB2

Basal cell carcinoma

hsa05217

0.0096687

WNT2, WNT5A, SMO, HHIP, GLI3

Hematopoietic cell lineage

hsa04640

0.0098799

CD34, FLT3, CD2, CSF3R, MME, EPO

MAPK signaling pathway

hsa04010

0.0201135

FGF5, FGF8, RASGRF1, NTRK2, MOS, TGFB3, FGF12, FGF2, FGF3, TGFB2

Melanoma

hsa05218

0.0229304

FGF5, FGF8, FGF12, FGF2, FGF3

TGF-beta signaling pathway

hsa04350

0.0437881

IFNG, TGFB3, THBS2, BMP6, TGFB2

Regulation of actin cytoskeleton

hsa04810

0.0456631

FGF5, FGF8, TIAM1, INS, MOS, FGF12, FGF2, FGF3

Axon guidance

hsa04360

0.0471078

DCC, EPHA7, EPHA8, SEMA3C, FES, SLIT2

Different between tumor subtype H and L

Pathways in cancer

hsa05200

0.0000012

DCC, WNT5A, FGF5, FGF8, RET, FLT3, MMP2, GLI3, TGFB2, WNT2, SMO, HHIP, CCNA1, FGF3

Hedgehog signaling pathway

hsa04340

0.0000843

WNT2, WNT5A, SMO, HHIP, GLI3, BMP6

Basal cell carcinoma

hsa05217

0.0010110

WNT2, WNT5A, SMO, HHIP, GLI3

Cytokine-cytokine receptor interaction

hsa04060

0.0194278

FLT1, FLT3, FLT4, NGFR, KDR, EPO, TGFB2