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Table 1 KEGG pathways of significantly differentially methylated genes
| Pathway | Entry | Pvalue (EASE score) | Genes |
|---|---|---|---|
| Different between tumor and tumor-adjacent gastric tissue | |||
| Pathways in cancer | hsa05200 | 0.0000014 | DCC, WNT5A, FGF5, RET, FGF8, FLT3, PPARG, TGFB3, FGF12, MMP2, GLI3, TGFB2, WNT2, SMO, CSF3R, HHIP, CCNA1, FGF2, FGF3 |
| Hedgehog signaling pathway | hsa04340 | 0.0015474 | WNT2, WNT5A, SMO, HHIP, GLI3, BMP6 |
| Cytokine-cytokine receptor interaction | hsa04060 | 0.0019703 | LIF, FLT1, FLT3, FLT4, IFNG, TGFB3, CSF3R, NGFR, KDR, TNFSF8, EPO, TGFB2 |
| Basal cell carcinoma | hsa05217 | 0.0096687 | WNT2, WNT5A, SMO, HHIP, GLI3 |
| Hematopoietic cell lineage | hsa04640 | 0.0098799 | CD34, FLT3, CD2, CSF3R, MME, EPO |
| MAPK signaling pathway | hsa04010 | 0.0201135 | FGF5, FGF8, RASGRF1, NTRK2, MOS, TGFB3, FGF12, FGF2, FGF3, TGFB2 |
| Melanoma | hsa05218 | 0.0229304 | FGF5, FGF8, FGF12, FGF2, FGF3 |
| TGF-beta signaling pathway | hsa04350 | 0.0437881 | IFNG, TGFB3, THBS2, BMP6, TGFB2 |
| Regulation of actin cytoskeleton | hsa04810 | 0.0456631 | FGF5, FGF8, TIAM1, INS, MOS, FGF12, FGF2, FGF3 |
| Axon guidance | hsa04360 | 0.0471078 | DCC, EPHA7, EPHA8, SEMA3C, FES, SLIT2 |
| Different between tumor subtype H and L | |||
| Pathways in cancer | hsa05200 | 0.0000012 | DCC, WNT5A, FGF5, FGF8, RET, FLT3, MMP2, GLI3, TGFB2, WNT2, SMO, HHIP, CCNA1, FGF3 |
| Hedgehog signaling pathway | hsa04340 | 0.0000843 | WNT2, WNT5A, SMO, HHIP, GLI3, BMP6 |
| Basal cell carcinoma | hsa05217 | 0.0010110 | WNT2, WNT5A, SMO, HHIP, GLI3 |
| Cytokine-cytokine receptor interaction | hsa04060 | 0.0194278 | FLT1, FLT3, FLT4, NGFR, KDR, EPO, TGFB2 |
