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Table 2 Area under the ROC curve (AUROC), sensitivity, specificity, and predictive values of sustained virological response based on a log 10 decrease in total HCV core antigen, across cutpoints and timepoints after initial antiviral treatment

From: Hepatitis C virus core antigen, an earlier and stronger predictor on sustained virological response in patients with genotype 1 HCV infection

  24 h 48 h 72 h 96 h 120 h 144 h - 1 144 h - 2 4 w 8 w 12 w
AUROC 0.835 0.814 0.870 0.866 0.879 0.913 0.913 0.853 0.823 0.719
(95% CI) (0.691-0.980) (0.663-0.965) (0.742-0.998) (0.738-0.994) (0.760-0.998) (0.799-1.000) (0.799-1.000) (0.720-0.985) (0.680-0.965) (0.520-0.917)
Cutoffa 0.785 1.090 1.034 1.262 1.138 0.976 1.096 3.231 3.780 3.770
Sensitivity 0.810 0.762 0.810 0.810 0.810 0.952 0.762 0.714 0.667 0.667
Specificity 0.818 0.727 0.818 0.818 0.818 0.700 0.800 0.909 1.000 0.818
PPV 1.000 1.000 1.000 1.000 1.000 0.913 1.000 1.000 1.000 1.000
NPV 0.846 0.846 0.846 0.846 0.846 1.000 0.769 0.687 0.611 0.687
  1. AUROC, areas under the univariate receiver operating characteristic curve; PPV, positive predictive value; NPV, negative predictive value.
  2. aCutoff was defined as change of log 10 fmol/L.