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Table 7 Comparison of the clinical characteristics of chronic hepatitis C patients with (A2–3) or without (A0–1) severe hepatic inflammation

From: Serum levels of apoptosis inhibitor of macrophage are associated with hepatic fibrosis in patients with chronic hepatitis C

   A0-A1   A2-A3    
   n = 32   n = 45    
Factor Mean or number Maximum Minimum Mean or number Maximum Minimum P value*
Age (years) 51.9 70 20 59.1 76 24 0.039
Sex (male/female) 14/18    17/28    0.598
Body mass index (kg/m2) 23.1 30.1 16.4 23.7 32.2 17.8 0.694
Platelets (×104/μl) 21.3 41.9 11.1 15.8 39.7 5.4 <0.001
Total cholesterol (mg/dl) 180.9 295 101 163.4 251 84 0.122
Albumin (g/dl) 4.4 5.1 3.3 4.2 4.9 2.9 0.003
ALT (IU/l) 42.2 165 13 80.3 244 14 0.003
γ-GTP (IU/l) 32.3 114 12 62.8 468 12 0.006
Diabetes (absent/present) 6/26    11/34    0.553
Fasting plasma glucose (mg/dl) 97.8 196 75 96.5 176 72 0.983
Hemoglobin A1c (%) 5.4 (n = 31) 7.6 4.6 5.4 (n = 44) 7.1 4.7 0.643
Leptin (ng/ml) 7.2 21.8 1 7.8 20.7 1.1 0.247
Adiponectin (ng/ml) 8.9 27.3 1.1 9 26.7 1.7 0.463
Resistin (ng/ml) 8.6 27.6 2.5 8.5 19.7 3 0.687
AIM (μg/ml) 1.17 4.56 0.41 1.54 6.44 0.76 0.001
Hyaluronic acid (ng/ml) 58.8 10.0 292.7 123.4 (n = 43) 12.1 636.0 0.001
  1. *Calculated by Chi-square test for categorical variables or Mann–Whitney U test for continuous variables.
  2. ALT, alanine aminotransferase; γGTP, γ-glutamyl transpeptidase; HOMA-IR, homeostasis model assessment-insulin resistance; AIM, apoptosis inhibitor of macrophage.