Skip to main content

Table 2 Pharmacokinetic measures in patients during dosing with lesogaberan 30 (n = 18), 90 (n = 20), 120 (n = 21) and 240 mg (n = 19)

From: Dose-dependent effects of lesogaberan on reflux measures in patients with refractory gastroesophageal reflux disease: a randomized, placebo-controlled study

Parameter Lesogaberan dose (mg) Geometric mean Coefficient of variation (%)
AUC (0–24 h) , μmol · h/l 30 5.25 46.4
  90 17.3 31.5
  120 22.2 44.8
  240 46.9 50.0
C max morning, μmol/l 30 0.35 59.2
  90 1.30 38.2
  120 1.48 53.5
  240 3.31 69.3
C max evening, μmol/l 30 0.42 59.5
  90 1.68 43.8
  120 2.21 50.3
  240 4.18 36.8
t max morning, h 30 1.7 25.2
  90 1.7 26.7
  120 1.9 53.1
  240 1.7 27.6
t max evening, h 30 2.2 56.4
  90 1.9 47.1
  120 1.9 35.9
  240 2.6 73.4
  1. AUC, area under the curve; Cmax, peak concentration; tmax, time to reach peak concentration.