Potential blood-based markers of celiac disease

BMC Gastroenterology

Table 1 Descriptive data on study subjects including clinical antibody levels

Group	No of cases^a(Females)	Age (years) median; 80% CR^b	Marsh grade span	Anti-TG2 (U/mL)^cmedian; 80% CR	Anti-DGP (U/mL)^dmedian; 80% CR	Anti-GL (U/mL)^emedian; 80% CR
Not CD	14 (8)	8.8; 2.2-16	Marsh 0-1	0.25; 0.05-11	0.95; 0.20-20	0.60; 0.10-2.4
Normalized CD^f	15 (13)	12; 7.3-17	Marsh 0-1	3.4; 0.40-28	2.6; 1.2-9.3	0.80; 0.20-4.1
Active CD^g	20 (12)	5.9; 1.5-14	Marsh 2-3C	201; 4.4-1997	64; 5.6-392	16; 2.4-167
Under investigation^h	3 (3)	15; 12-16	Marsh 0-1	15; 10-16	7.1; 2.1-22	1.9; 0.50-6.5

Study subjects are divided into groups depending on the diagnosis and the histopathologic assessment.
^aInitially, a total of 56 cases were included in the study, but three cases were later excluded due to low sample amount and one case was excluded due to histopathologically non-assessable biopsies, leaving 52 cases included in the analyses.
^bCR = Central range.
^cTissue transglutaminase autoantibodies (anti-TG2), positive result ≥ 7 U/mL.
^dDeamidated gliadin antibodies (anti-DGP), positive result ≥ 10 U/mL.
^eGliadin antibodies (anti-GL), positive result ≥ 7 U/mL.
^fCases with confirmed celiac disease and duodenal biopsies indicating a Marsh grade 0–1, on a gluten-containing diet (n = 1) or a gluten-free diet (n = 14). Two cases had suboptimal (but assessable) biopsies.
^gCases with duodenal biopsies indicating a Marsh grade 2-3C, on a gluten-containing diet (n = 18) or a gluten-free diet (n = 2). One case had patchy lesions of the small intestine.
^hCases under continued gluten challenge and observation due to elevated antibody titers but normal mucosa. Ranges for this group are represented by minimum and maximum values.

ISSN: 1471-230X