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Table 1 Descriptive data on study subjects including clinical antibody levels

From: Potential blood-based markers of celiac disease

Group No of casesa(Females) Age (years) median; 80% CRb Marsh grade span Anti-TG2 (U/mL)cmedian; 80% CR Anti-DGP (U/mL)dmedian; 80% CR Anti-GL (U/mL)emedian; 80% CR
Not CD 14 (8) 8.8; 2.2-16 Marsh 0-1 0.25; 0.05-11 0.95; 0.20-20 0.60; 0.10-2.4
Normalized CDf 15 (13) 12; 7.3-17 Marsh 0-1 3.4; 0.40-28 2.6; 1.2-9.3 0.80; 0.20-4.1
Active CDg 20 (12) 5.9; 1.5-14 Marsh 2-3C 201; 4.4-1997 64; 5.6-392 16; 2.4-167
Under investigationh 3 (3) 15; 12-16 Marsh 0-1 15; 10-16 7.1; 2.1-22 1.9; 0.50-6.5
  1. Study subjects are divided into groups depending on the diagnosis and the histopathologic assessment.
  2. aInitially, a total of 56 cases were included in the study, but three cases were later excluded due to low sample amount and one case was excluded due to histopathologically non-assessable biopsies, leaving 52 cases included in the analyses.
  3. bCR = Central range.
  4. cTissue transglutaminase autoantibodies (anti-TG2), positive result ≥ 7 U/mL.
  5. dDeamidated gliadin antibodies (anti-DGP), positive result ≥ 10 U/mL.
  6. eGliadin antibodies (anti-GL), positive result ≥ 7 U/mL.
  7. fCases with confirmed celiac disease and duodenal biopsies indicating a Marsh grade 0–1, on a gluten-containing diet (n = 1) or a gluten-free diet (n = 14). Two cases had suboptimal (but assessable) biopsies.
  8. gCases with duodenal biopsies indicating a Marsh grade 2-3C, on a gluten-containing diet (n = 18) or a gluten-free diet (n = 2). One case had patchy lesions of the small intestine.
  9. hCases under continued gluten challenge and observation due to elevated antibody titers but normal mucosa. Ranges for this group are represented by minimum and maximum values.