Figure 6
Combined treatment with N-acetyl-cysteine (NAC) and neostigmine show an additive effect in acute liver failure (ALF) induced by acetaminophen (APAP). All mice were treated with a dosing of 750 mg/kg APAP i.p. and a therapeutical treatment with 75 mg/kg NAC i.p. after 2 hours (solid line) or in a combined set-up with 75 mg/kg NAC after 2 hours and successive applications of neostigmine (80 μg/kg) i.p. after 2, 7, 12 and 24 hours (dashed line, plog-rank = 0.0260; n = 8 for each group). Mice were monitored for 48 hours.