Figure 2

Serum levels of lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) after acetaminophen (APAP)-induced liver injury are reduced by cholinesterase inhibition. 12 hours after application of 600 mg/kg APAP i.p., serum was collected from neostigmine-treated (80 μg/kg i.p. 1 and 7 hours after application of APAP) and control mice. LDH and serum-transaminases were measured (mean ± SD; open bars, control mice, hatched bars, APAP + solvent, filled bars, APAP + neostigmine; n = 6 for each group; **p < 0.01 APAP-alone-treated mice vs. APAP + neostigmine-treated mice).