Figure 1
Cholinesterase inhibition protects against acute liver failure (ALF) induced by acetaminophen (APAP). All mice received 600 mg/kg APAP i.p.. Neostigmine-treated animals received 80 μg/kg neostigmine 1 hour prior to application of APAP and 7, 12 and 24 hours thereafter (dotted line, plog-rank = 0.0046) or 1, 7, 12 and 24 hours after application of APAP (dashed line, plog-rank = 0.1860). Control mice received solvent (0.9% NaCl) 1, 7, 12 and 24 hours after application of APAP (solid line; n = 6 for each group).