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Table 5 Summary of the areas under the ROC curves (AUC) for AFP and APRI

From: Alpha-fetoprotein level as a biomarker of liver fibrosis status: a cross-sectional study of 619 consecutive patients with chronic hepatitis B

 

Inflammation

Fibrosis

AUC (95% CI)

AUC (95% CI)

Judging stage ≥ 2

AFP

0.685 (0.647 - 0.722)

0.691 (0.653 to 0.727)

APRI

0.741 (0.704 - 0.775)

0.687 (0.649 - 0.723)

P-value

0.074

0.897

Judging stage ≥ 3

AFP

0.727 (0.690 - 0.762)

0.717 (0.680 to 0.752)

APRI

0.746 (0.709 - 0.779)

0.649 (0.610 - 0.687)

P-value

0.430

0.007*

Judging stage = 4

AFP

0.755 (0.719 - 0.789)

0.718 (0.681 to 0.753)

APRI

0.714 (0.677 - 0.750)

0.618 (0.578 - 0.656)

P-value

0.221

<0.001*

  1. *P < 0.05 indicate a significant difference between AUCs of AFP and APRI.
  2. ROC, receiver operating characteristic; AUC, area under the curve.
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BMC Gastroenterology

ISSN: 1471-230X

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